Continuous microfluidic immunomagnetic cell separation

David W. Inglis, R. Riehn, R. H. Austin, J. C. Sturm

Research output: Contribution to journalArticlepeer-review

292 Scopus citations

Abstract

We present a continuous-flow microfluidic device that enables cell by cell separation of cells selectively tagged with magnetic nanoparticles. The cells flow over an array of microfabricated magnetic stripes, which create a series of high magnetic field gradients that trap the magnetically labeled cells and alter their flow direction. The process was observed in real time using a low power microscope. The device has been demonstrated by the separation of leukocytes from whole human blood.

Original languageEnglish (US)
Pages (from-to)5093-5095
Number of pages3
JournalApplied Physics Letters
Volume85
Issue number21
DOIs
StatePublished - Nov 2004

All Science Journal Classification (ASJC) codes

  • Physics and Astronomy (miscellaneous)

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