Continuous manipulation of mental representations is compromised in cerebellar degeneration

Samuel D. McDougle, Jonathan S. Tsay, Benjamin Pitt, Maedbh King, William Saban, Jordan A. Taylor, Richard B. Ivry

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

We introduce a novel perspective on how the cerebellum might contribute to cognition, hypothesizing that this structure supports dynamic transformations of mental representations. In support of this hypothesis, we report a series of neuropsychological experiments comparing the performance of individuals with degenerative cerebellar disorders on tasks that either entail continuous, movement-like mental operations or more discrete mental operations. In the domain of visual cognition, the cerebellar disorders group exhibited an impaired rate of mental rotation, an operation hypothesized to require the continuous manipulation of a visual representation. In contrast, the cerebellar disorders group showed a normal processing rate when scanning items in visual working memory, an operation hypothesized to require the maintenance and retrieval of remembered items. In the domain of mathematical cognition, the cerebellar disorders group was impaired at single-digit addition, an operation hypothesized to primarily require iterative manipulations along a mental number-line; this group was not impaired on arithmetic tasks linked to memory retrieval (e.g. single-digit multiplication). These results, obtained in tasks from two disparate domains, point to a potential constraint on the contribution of the cerebellum to cognitive tasks. Paralleling its role in motor control, the cerebellum may be essential for coordinating dynamic, movement-like transformations in a mental workspace.

Original languageEnglish (US)
Pages (from-to)4246-4263
Number of pages18
JournalBrain
Volume145
Issue number12
DOIs
StatePublished - Dec 1 2022

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

Keywords

  • cerebellum
  • mental imagery
  • mental operations
  • spinocerebellar ataxia

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