Continuous control in bacterial regulatory circuits

Eric Batchelor, Thomas J. Silhavy, Mark Goulian

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


We show that for two well-characterized regulatory circuits in Escherichia coli, Tn10 tetracycline resistance and porin osmoregulation, the transcriptional outputs in individual cells are graded functions of the applied stimuli. These systems are therefore examples of naturally occurring regulatory circuits that exhibit continuous control of transcription. Surprisingly, however, we find that porin osmoregulation is open loop; i.e., the porin expression level does not feed back into the regulatory circuit. This mode of control is particularly interesting for an organism such as E. coli, which proliferates in diverse environments, and raises important questions regarding the biologically relevant inputs and outputs for this system.

Original languageEnglish (US)
Pages (from-to)7618-7625
Number of pages8
JournalJournal of bacteriology
Issue number22
StatePublished - Nov 2004

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Microbiology


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