Context, cortex, and dopamine: A Connectionist approach to behavior and biology in schizophrenia

Jonathan D. Cohen, David Servan-Schreiber

Research output: Contribution to journalArticlepeer-review

1173 Scopus citations


Connectionist models are used to explore the relationship between cognitive deficits and biological abnormalities in schizophrenia. Schizophrenic deficits in tasks that tap attention and language processing are reviewed, as are biological disturbances involving prefrontal cortex and the mesocortical dopamine system. Three computer models are then presented that simulate normal and schizophrenic performance in the Stroop task, the continuous performance test, and a lexical disambiguation task. They demonstrate that a disturbance in the internal representation of contextual information can provide a common explanation for schizophrenic deficits in several attentionand language-related tasks. The models also show that these behavioral deficits may arise from a disturbance in a model parameter (gain) corresponding to the neuromodulatory effects of dopamine, in a model component corresponding to the function of prefrontal cortex.

Original languageEnglish (US)
Pages (from-to)45-77
Number of pages33
JournalPsychological Review
Issue number1
StatePublished - 1992
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Psychology


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