Construction and physical mapping of the 35cM YAC contigs for the region of Xp11. 2 - P21.3

Yong Wei, Xue Jun Wu, Wei Min Miao, Ti Cai, Xiao Hui Wu, Yi Bin Kang, Jian Hua Chai

Research output: Contribution to journalArticle

Abstract

One hundred and fifty-one YACs were selected from three libraries with a series of STS and other DNA probes of the human X chromosome p11.2 - p21. 3 region. The YAC contigs, spanning about 35cM in all and generally cover the whole region,were constructed based on the physical analysis of the positive clones. A total of seventy-seven DNA markers of this region were located and ordered on this map with an average 454 kb spacing,in which fifty-three were polymorphic markers with an average 0.6cM genetic spacing. These results facilitate the search for novel genes and the sequence analysis of this region.

Original languageEnglish (US)
Pages (from-to)105-106
Number of pages2
JournalActa Biochimica et Biophysica Sinica
Volume29
Issue number1
StatePublished - Dec 1 1997
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry

Keywords

  • Physical map
  • STS
  • X chromosome
  • YAC contig

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    Wei, Y., Wu, X. J., Miao, W. M., Cai, T., Wu, X. H., Kang, Y. B., & Chai, J. H. (1997). Construction and physical mapping of the 35cM YAC contigs for the region of Xp11. 2 - P21.3. Acta Biochimica et Biophysica Sinica, 29(1), 105-106.