Consortium biology in immunology: The perspective from the Immunological Genome Project

Christophe Benoist; Lewis Lanier; Miriam Merad; Diane Mathis; Jeff Ericson; Michio Painter; Scott Davis; Catherine Laplace; Gordon Hyatt; Henry Paik; Katie Rothamel; Richard Cruse; Graeme Doran; Tracy Heng; Natasha Asinovski; Adriana Ortiz-Lopes; Ayla Ergun; Daniel Gray; Ei Wakamatsu; Jonathan Hill; Michael Mingueneau; Daniela Cipolletta; Hideyuki Yoshida; Nadia Cohen; Edy Kim; Patrick Brennan; Lydia Lynch; Michael Brenner; James Costello; Jim J. Collins; David Blair; Michael Dustin; Jamie Knell; Edward Yang; Adam Best; Laura Shaw; Andrew Doedens; Ananda Goldrath; Susan Shinton; Yan Zhou; Randy Hardy; Vladimir Jojic; Sara Mostafavi; Daphne Koller; Radu Jianu; David Laidlaw; Natalie Bezman; Joseph Sun; Yanan Zhu; Deborah Hendricks; Yosuke Kamimura; Gundula Min-Oo; Deborah Hendricks; Maelig Morvan; Yosuke Kamimura; Tsukasa Nabekura; Viola Lam; Charles Kim; Melanie Greter; Julie Helft; Andrew Chow; Milena Bogunovic; Arthur Mortha; Jeremy Price; Daigo Hashimoto; Jennifer Miller; Priyanka Sathe; Aleksey Chudnovskiy; Yonit Lavin; Juliana Idoyaga; Emmanuel Gautier; Claudia Jakubzick; June D'Angelo; Gwendolyn Randolph; Tal Shay; Aviv Regev; Roi Gazit; Derrick Rossi; Taras Kreslawsky; Harald von Bohmer; Angelique Bellemare-Pelletier; Kutlu Elpek; Lotte Spelv; Anne Fletcher; Deepali Malhotra; Viviana Cremasco; Shannon Turley; Francis Kim; Tata Nageswara Rao; Amy Wagers

doi:10.1038/nri3300

Consortium biology in immunology: The perspective from the Immunological Genome Project

Christophe Benoist, Lewis Lanier, Miriam Merad, Diane Mathis, Jeff Ericson, Michio Painter, Scott Davis, Catherine Laplace, Gordon Hyatt, Henry Paik, Katie Rothamel, Richard Cruse, Graeme Doran, Tracy Heng, Natasha Asinovski, Adriana Ortiz-Lopes, Ayla Ergun, Daniel Gray, Ei Wakamatsu, Jonathan HillMichael Mingueneau, Daniela Cipolletta, Hideyuki Yoshida, Nadia Cohen, Edy Kim, Patrick Brennan, Lydia Lynch, Michael Brenner, James Costello, Jim J. Collins, David Blair, Michael Dustin, Jamie Knell, Edward Yang, Adam Best, Laura Shaw, Andrew Doedens, Ananda Goldrath, Susan Shinton, Yan Zhou, Randy Hardy, Vladimir Jojic, Sara Mostafavi, Daphne Koller, Radu Jianu, David Laidlaw, Natalie Bezman, Joseph Sun, Yanan Zhu, Deborah Hendricks, Yosuke Kamimura, Gundula Min-Oo, Deborah Hendricks, Maelig Morvan, Yosuke Kamimura, Tsukasa Nabekura, Viola Lam, Charles Kim, Melanie Greter, Julie Helft, Andrew Chow, Milena Bogunovic, Arthur Mortha, Jeremy Price, Daigo Hashimoto, Jennifer Miller, Priyanka Sathe, Aleksey Chudnovskiy, Yonit Lavin, Juliana Idoyaga, Emmanuel Gautier, Claudia Jakubzick, June D'Angelo, Gwendolyn Randolph, Tal Shay, Aviv Regev, Roi Gazit, Derrick Rossi, Taras Kreslawsky, Harald von Bohmer, Angelique Bellemare-Pelletier, Kutlu Elpek, Lotte Spelv, Anne Fletcher, Deepali Malhotra, Viviana Cremasco, Shannon Turley, Francis Kim, Tata Nageswara Rao, Amy Wagers

Molecular Biology

Research output: Contribution to journal › Review article › peer-review

29 Scopus citations

Abstract

Although the field has a long collaborative tradition, immunology has made less use than genetics of 'consortium biology', wherein groups of investigators together tackle large integrated questions or problems. However, immunology is naturally suited to large-scale integrative and systems-level approaches, owing to the multicellular and adaptive nature of the cells it encompasses. Here, we discuss the value and drawbacks of this organization of research, in the context of the long-running 'big science' debate, and consider the opportunities that may exist for the immunology community. We position this analysis in light of our own experience, both positive and negative, as participants of the Immunological Genome Project.

Original language	English (US)
Pages (from-to)	734-740
Number of pages	7
Journal	Nature Reviews Immunology
Volume	12
Issue number	10
DOIs	https://doi.org/10.1038/nri3300
State	Published - Oct 1 2012

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology

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10.1038/nri3300

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Benoist, C., Lanier, L., Merad, M., Mathis, D., Ericson, J., Painter, M., Davis, S., Laplace, C., Hyatt, G., Paik, H., Rothamel, K., Cruse, R., Doran, G., Heng, T., Asinovski, N., Ortiz-Lopes, A., Ergun, A., Gray, D., Wakamatsu, E., ... Wagers, A. (2012). Consortium biology in immunology: The perspective from the Immunological Genome Project. Nature Reviews Immunology, 12(10), 734-740. https://doi.org/10.1038/nri3300

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title = "Consortium biology in immunology: The perspective from the Immunological Genome Project",

abstract = "Although the field has a long collaborative tradition, immunology has made less use than genetics of 'consortium biology', wherein groups of investigators together tackle large integrated questions or problems. However, immunology is naturally suited to large-scale integrative and systems-level approaches, owing to the multicellular and adaptive nature of the cells it encompasses. Here, we discuss the value and drawbacks of this organization of research, in the context of the long-running 'big science' debate, and consider the opportunities that may exist for the immunology community. We position this analysis in light of our own experience, both positive and negative, as participants of the Immunological Genome Project.",

author = "Christophe Benoist and Lewis Lanier and Miriam Merad and Diane Mathis and Jeff Ericson and Michio Painter and Scott Davis and Catherine Laplace and Gordon Hyatt and Henry Paik and Katie Rothamel and Richard Cruse and Graeme Doran and Tracy Heng and Natasha Asinovski and Adriana Ortiz-Lopes and Ayla Ergun and Daniel Gray and Ei Wakamatsu and Jonathan Hill and Michael Mingueneau and Daniela Cipolletta and Hideyuki Yoshida and Nadia Cohen and Edy Kim and Patrick Brennan and Lydia Lynch and Michael Brenner and James Costello and Collins, {Jim J.} and David Blair and Michael Dustin and Jamie Knell and Edward Yang and Adam Best and Laura Shaw and Andrew Doedens and Ananda Goldrath and Susan Shinton and Yan Zhou and Randy Hardy and Vladimir Jojic and Sara Mostafavi and Daphne Koller and Radu Jianu and David Laidlaw and Natalie Bezman and Joseph Sun and Yanan Zhu and Deborah Hendricks and Yosuke Kamimura and Gundula Min-Oo and Deborah Hendricks and Maelig Morvan and Yosuke Kamimura and Tsukasa Nabekura and Viola Lam and Charles Kim and Melanie Greter and Julie Helft and Andrew Chow and Milena Bogunovic and Arthur Mortha and Jeremy Price and Daigo Hashimoto and Jennifer Miller and Priyanka Sathe and Aleksey Chudnovskiy and Yonit Lavin and Juliana Idoyaga and Emmanuel Gautier and Claudia Jakubzick and June D'Angelo and Gwendolyn Randolph and Tal Shay and Aviv Regev and Roi Gazit and Derrick Rossi and Taras Kreslawsky and {von Bohmer}, Harald and Angelique Bellemare-Pelletier and Kutlu Elpek and Lotte Spelv and Anne Fletcher and Deepali Malhotra and Viviana Cremasco and Shannon Turley and Francis Kim and {Nageswara Rao}, Tata and Amy Wagers",

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doi = "10.1038/nri3300",

language = "English (US)",

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Benoist, C, Lanier, L, Merad, M, Mathis, D, Ericson, J, Painter, M, Davis, S, Laplace, C, Hyatt, G, Paik, H, Rothamel, K, Cruse, R, Doran, G, Heng, T, Asinovski, N, Ortiz-Lopes, A, Ergun, A, Gray, D, Wakamatsu, E, Hill, J, Mingueneau, M, Cipolletta, D, Yoshida, H, Cohen, N, Kim, E, Brennan, P, Lynch, L, Brenner, M, Costello, J, Collins, JJ, Blair, D, Dustin, M, Knell, J, Yang, E, Best, A, Shaw, L, Doedens, A, Goldrath, A, Shinton, S, Zhou, Y, Hardy, R, Jojic, V, Mostafavi, S, Koller, D, Jianu, R, Laidlaw, D, Bezman, N, Sun, J, Zhu, Y, Hendricks, D, Kamimura, Y, Min-Oo, G, Hendricks, D, Morvan, M, Kamimura, Y, Nabekura, T, Lam, V, Kim, C, Greter, M, Helft, J, Chow, A, Bogunovic, M, Mortha, A, Price, J, Hashimoto, D, Miller, J, Sathe, P, Chudnovskiy, A, Lavin, Y, Idoyaga, J, Gautier, E, Jakubzick, C, D'Angelo, J, Randolph, G, Shay, T, Regev, A, Gazit, R, Rossi, D, Kreslawsky, T, von Bohmer, H, Bellemare-Pelletier, A, Elpek, K, Spelv, L, Fletcher, A, Malhotra, D, Cremasco, V, Turley, S, Kim, F, Nageswara Rao, T & Wagers, A 2012, 'Consortium biology in immunology: The perspective from the Immunological Genome Project', Nature Reviews Immunology, vol. 12, no. 10, pp. 734-740. https://doi.org/10.1038/nri3300

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T2 - The perspective from the Immunological Genome Project

AU - Benoist, Christophe

AU - Lanier, Lewis

AU - Merad, Miriam

AU - Mathis, Diane

AU - Ericson, Jeff

AU - Painter, Michio

AU - Davis, Scott

AU - Laplace, Catherine

AU - Hyatt, Gordon

AU - Paik, Henry

AU - Rothamel, Katie

AU - Cruse, Richard

AU - Doran, Graeme

AU - Heng, Tracy

AU - Asinovski, Natasha

AU - Ortiz-Lopes, Adriana

AU - Ergun, Ayla

AU - Gray, Daniel

AU - Wakamatsu, Ei

AU - Hill, Jonathan

AU - Mingueneau, Michael

AU - Cipolletta, Daniela

AU - Yoshida, Hideyuki

AU - Cohen, Nadia

AU - Kim, Edy

AU - Brennan, Patrick

AU - Lynch, Lydia

AU - Brenner, Michael

AU - Costello, James

AU - Collins, Jim J.

AU - Blair, David

AU - Dustin, Michael

AU - Knell, Jamie

AU - Yang, Edward

AU - Best, Adam

AU - Shaw, Laura

AU - Doedens, Andrew

AU - Goldrath, Ananda

AU - Shinton, Susan

AU - Zhou, Yan

AU - Hardy, Randy

AU - Jojic, Vladimir

AU - Mostafavi, Sara

AU - Koller, Daphne

AU - Jianu, Radu

AU - Laidlaw, David

AU - Bezman, Natalie

AU - Sun, Joseph

AU - Zhu, Yanan

AU - Hendricks, Deborah

AU - Kamimura, Yosuke

AU - Min-Oo, Gundula

AU - Hendricks, Deborah

AU - Morvan, Maelig

AU - Kamimura, Yosuke

AU - Nabekura, Tsukasa

AU - Lam, Viola

AU - Kim, Charles

AU - Greter, Melanie

AU - Helft, Julie

AU - Chow, Andrew

AU - Bogunovic, Milena

AU - Mortha, Arthur

AU - Price, Jeremy

AU - Hashimoto, Daigo

AU - Miller, Jennifer

AU - Sathe, Priyanka

AU - Chudnovskiy, Aleksey

AU - Lavin, Yonit

AU - Idoyaga, Juliana

AU - Gautier, Emmanuel

AU - Jakubzick, Claudia

AU - D'Angelo, June

AU - Randolph, Gwendolyn

AU - Shay, Tal

AU - Regev, Aviv

AU - Gazit, Roi

AU - Rossi, Derrick

AU - Kreslawsky, Taras

AU - von Bohmer, Harald

AU - Bellemare-Pelletier, Angelique

AU - Elpek, Kutlu

AU - Spelv, Lotte

AU - Fletcher, Anne

AU - Malhotra, Deepali

AU - Cremasco, Viviana

AU - Turley, Shannon

AU - Kim, Francis

AU - Nageswara Rao, Tata

AU - Wagers, Amy

PY - 2012/10/1

Y1 - 2012/10/1

N2 - Although the field has a long collaborative tradition, immunology has made less use than genetics of 'consortium biology', wherein groups of investigators together tackle large integrated questions or problems. However, immunology is naturally suited to large-scale integrative and systems-level approaches, owing to the multicellular and adaptive nature of the cells it encompasses. Here, we discuss the value and drawbacks of this organization of research, in the context of the long-running 'big science' debate, and consider the opportunities that may exist for the immunology community. We position this analysis in light of our own experience, both positive and negative, as participants of the Immunological Genome Project.

AB - Although the field has a long collaborative tradition, immunology has made less use than genetics of 'consortium biology', wherein groups of investigators together tackle large integrated questions or problems. However, immunology is naturally suited to large-scale integrative and systems-level approaches, owing to the multicellular and adaptive nature of the cells it encompasses. Here, we discuss the value and drawbacks of this organization of research, in the context of the long-running 'big science' debate, and consider the opportunities that may exist for the immunology community. We position this analysis in light of our own experience, both positive and negative, as participants of the Immunological Genome Project.

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JO - Nature Reviews Immunology

JF - Nature Reviews Immunology

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ER -

Consortium biology in immunology: The perspective from the Immunological Genome Project

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All Science Journal Classification (ASJC) codes

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