Conserved regulators of cognitive aging: From worms to humans

Rachel N. Arey, Coleen T. Murphy

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Cognitive decline is a major deficit that arises with age in humans. While some research on the underlying causes of these problems can be done in humans, harnessing the strengths of small model systems, particularly those with well-studied longevity mutants, such as the nematode C. elegans, will accelerate progress. Here we review the approaches being used to study cognitive decline in model organisms and show how simple model systems allow the rapid discovery of conserved molecular mechanisms, which will eventually enable the development of therapeutics to slow cognitive aging.

Original languageEnglish (US)
Pages (from-to)299-310
Number of pages12
JournalBehavioural Brain Research
StatePublished - Mar 30 2017

All Science Journal Classification (ASJC) codes

  • Behavioral Neuroscience


  • Aging
  • Cognitive aging
  • Cognitive decline
  • Longevity
  • Model systems


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