Connecting Neural Codes with Behavior in the Auditory System of Drosophila

Jan Clemens, Cyrille C. Girardin, Philip Coen, Xiao Juan Guan, Barry J. Dickson, Mala Murthy

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

Brains are optimized for processing ethologically relevant sensory signals. However, few studies have characterized the neural coding mechanisms that underlie the transformation from natural sensory information to behavior. Here, we focus on acoustic communication in Drosophila melanogaster and use computational modeling to link natural courtship song, neuronal codes, and female behavioral responses to song. We show that melanogaster females are sensitive to long timescale song structure (on the order of tens of seconds). From intracellular recordings, we generate models that recapitulate neural responses to acoustic stimuli. We link these neural codes with female behavior by generating model neural responses to natural courtship song. Using a simple decoder, we predict female behavioral responses to the same song stimuli with high accuracy. Our modeling approach reveals how long timescale song features are represented by the Drosophila brain and how neural representations can be decoded to generate behavioral selectivity for acoustic communication signals. Clemens et al. study neural representations of courtship song in the Drosophila auditory system. By combining neural recordings, behavioral assays, and modeling, they show that females integrate song information and propose simple computations for predicting female behavior from single neuron responses.

Original languageEnglish (US)
Pages (from-to)1332-1343
Number of pages12
JournalNeuron
Volume87
Issue number6
DOIs
StatePublished - Sep 23 2015

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Connecting Neural Codes with Behavior in the Auditory System of Drosophila'. Together they form a unique fingerprint.

  • Cite this

    Clemens, J., Girardin, C. C., Coen, P., Guan, X. J., Dickson, B. J., & Murthy, M. (2015). Connecting Neural Codes with Behavior in the Auditory System of Drosophila. Neuron, 87(6), 1332-1343. https://doi.org/10.1016/j.neuron.2015.08.014