TY - JOUR
T1 - Confined bilayers passively regulate shape and stress
AU - Staykova, Margarita
AU - Arroyo, Marino
AU - Rahimi, Mohammad
AU - Stone, Howard A.
PY - 2013/1/9
Y1 - 2013/1/9
N2 - Lipid membranes are commonly confined to adjacent subcellular structures or to artificial substrates and particles. We develop an experimental and theoretical framework to investigate the mechanics of confined membranes, including the influence of adhesion, strain, and osmotic pressure. We find that supported lipid bilayers respond to stress by nucleating and evolving spherical and tubular protrusions. In cells, such transformations are generally attributed to proteins. Our results offer insights into the mechanics of cell membranes and can further extend the applications of supported bilayers.
AB - Lipid membranes are commonly confined to adjacent subcellular structures or to artificial substrates and particles. We develop an experimental and theoretical framework to investigate the mechanics of confined membranes, including the influence of adhesion, strain, and osmotic pressure. We find that supported lipid bilayers respond to stress by nucleating and evolving spherical and tubular protrusions. In cells, such transformations are generally attributed to proteins. Our results offer insights into the mechanics of cell membranes and can further extend the applications of supported bilayers.
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U2 - 10.1103/PhysRevLett.110.028101
DO - 10.1103/PhysRevLett.110.028101
M3 - Article
C2 - 23383939
AN - SCOPUS:84872139983
SN - 0031-9007
VL - 110
JO - Physical review letters
JF - Physical review letters
IS - 2
M1 - 028101
ER -