Complex movements evoked by microstimulation of precentral cortex

Michael S.A. Graziano, Charlotte S.R. Taylor, Tirin Moore

Research output: Contribution to journalArticle

591 Scopus citations

Abstract

Electrical microstimulation was used to study primary motor and premotor cortex in monkeys. Each stimulation train was 500 ms in duration, approximating the time scale of normal reaching and grasping movements and the time scale of the neuronal activity that normally accompanies movement. This stimulation on a behaviorally relevant time scale evoked coordinated, complex postures that involved many joints. For example, stimulation of one site caused the mouth to open and also caused the hand to shape into a grip posture and move to the mouth. Stimulation of this site always drove the joints toward this final posture, regardless of the direction of movement required to reach the posture. Stimulation of other cortical sites evoked different postures. Postures that involved the arm were arranged across cortex to form a map of hand positions around the body. This stimulation-evoked map encompassed both primary motor and the adjacent premotor cortex. We suggest that these regions fit together into a single map of the workspace around the body.

Original languageEnglish (US)
Pages (from-to)841-851
Number of pages11
JournalNeuron
Volume34
Issue number5
DOIs
StatePublished - May 30 2002

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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