Complex interplay between tumor microenvironment and cancer therapy

Minhong Shen, Yibin Kang

Research output: Contribution to journalReview article

5 Scopus citations

Abstract

Tumor microenvironment (TME) is comprised of cellular and non-cellular components that exist within and around the tumor mass. The TME is highly dynamic and its importance in different stages of cancer progression has been well recognized. A growing body of evidence suggests that TME also plays pivotal roles in cancer treatment responses. TME is significantly remodeled upon cancer therapies, and such change either enhances the responses or induces drug resistance. Given the importance of TME in tumor progression and therapy resistance, strategies that remodel TME to improve therapeutic responses are under developing. In this review, we provide an overview of the essential components in TME and the remodeling of TME in response to anti-cancer treatments. We also summarize the strategies that aim to enhance therapeutic efficacy by modulating TME.

Original languageEnglish (US)
Pages (from-to)426-439
Number of pages14
JournalFrontiers of Medicine
Volume12
Issue number4
DOIs
StatePublished - Aug 1 2018

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Keywords

  • therapy response
  • treatment resistance
  • tumor microenvironment

Fingerprint Dive into the research topics of 'Complex interplay between tumor microenvironment and cancer therapy'. Together they form a unique fingerprint.

  • Cite this