Complementation analysis of pseudorabies virus gE and gI mutants in retinal ganglion cell neurotropism

L. W. Enquist, J. Dubin, M. E. Whealy, J. P. Card

Research output: Contribution to journalComment/debate

63 Scopus citations

Abstract

Pseudorabies virus glycoproteins gE and gI are required to infect some, but not all, regions of the rodent central nervous system after peripheral injection. After injection of the retina, pseudorabies virus mutants lacking either gE or gI can subsequently infect neural centers involved in the control of circadian function but cannot infect visual circuits mediating visual perception or the reflex movement of the eyes. In this study, we used genetic complementation to test the hypothesis that gE and gI are required for entry into the specific retinal ganglion cells that project to visual centers. These data strongly suggest that gE and gI must function after the viruses enter primary neurons in the retina.

Original languageEnglish (US)
Pages (from-to)5275-5279
Number of pages5
JournalJournal of virology
Volume68
Issue number8
DOIs
StatePublished - Aug 1994

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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