Complementary stereochemical outcomes in proline-based self-regenerations of stereocenters

Brian J. Knight, Erin E. Stache, Eric M. Ferreira

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Stereoselective alkylations of proline-based amino amides are described, where high levels of either a cis or trans configuration can be attained simply by the choice of the aminal group. Isobutryaldehyde-derived aminals provide the cis configuration, while 1-naphthaldehyde-derived aminals engender the complementary trans configuration.

Original languageEnglish (US)
Pages (from-to)432-435
Number of pages4
JournalOrganic letters
Issue number2
StatePublished - Jan 17 2014
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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