Complementary integration of organic electrochemical transistors for front-end amplifier circuits of flexible neural implants

Ilke Uguz, David Ohayon, Sinan Yilmaz, Sophie Griggs, Rajendar Sheelamanthula, Jason D. Fabbri, Iain McCulloch, Sahika Inal, Kenneth L. Shepard

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The ability to amplify, translate, and process small ionic potential fluctuations of neural processes directly at the recording site is essential to improve the performance of neural implants. Organic front-end analog electronics are ideal for this application, allowing for minimally invasive amplifiers owing to their tissue-like mechanical properties. Here, we demonstrate fully organic complementary circuits by pairing depletion- and enhancement-mode p- and n-type organic electrochemical transistors (OECTs). With precise geometry tuning and a vertical device architecture, we achieve overlapping output characteristics and integrate them into amplifiers with single neuronal dimensions (20 micrometers). Amplifiers with combined p- and n-OECTs result in voltage-to-voltage amplification with a gain of >30 decibels. We also leverage depletion and enhancement-mode p-OECTs with matching characteristics to demonstrate a differential recording capability with high common mode rejection rate (>60 decibels). Integrating OECT-based front-end amplifiers into a flexible shank form factor enables single-neuron recording in the mouse cortex with on-site filtering and amplification.

Original languageEnglish (US)
Article numbereadi9710
JournalScience Advances
Volume10
Issue number12
DOIs
StatePublished - Mar 2024
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General

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