Complement-Mediated Microglial Clearance of Developing Retinal Ganglion Cell Axons

Carolyn M. Tyler; Lisa M. Boulanger

doi:10.1016/j.neuron.2012.05.002

Complement-Mediated Microglial Clearance of Developing Retinal Ganglion Cell Axons

Carolyn M. Tyler, Lisa M. Boulanger

Research output: Contribution to journal › Short survey › peer-review

14 Scopus citations

Abstract

In many parts of the developing vertebrate nervous system, axons are pruned to establish mature patterns of connectivity. In this issue of Neuron, Schafer et al. (2012) show that microglia may play a role in developmental axon pruning in the thalamus by engulfing presynaptic retinal ganglion cell terminals via a C3- and CR3-dependent mechanism.

Original language	English (US)
Pages (from-to)	597-599
Number of pages	3
Journal	Neuron
Volume	74
Issue number	4
DOIs	https://doi.org/10.1016/j.neuron.2012.05.002
State	Published - May 24 2012

All Science Journal Classification (ASJC) codes

General Neuroscience

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10.1016/j.neuron.2012.05.002

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title = "Complement-Mediated Microglial Clearance of Developing Retinal Ganglion Cell Axons",

abstract = "In many parts of the developing vertebrate nervous system, axons are pruned to establish mature patterns of connectivity. In this issue of Neuron, Schafer et al. (2012) show that microglia may play a role in developmental axon pruning in the thalamus by engulfing presynaptic retinal ganglion cell terminals via a C3- and CR3-dependent mechanism.",

author = "Tyler, {Carolyn M.} and Boulanger, {Lisa M.}",

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T1 - Complement-Mediated Microglial Clearance of Developing Retinal Ganglion Cell Axons

AU - Tyler, Carolyn M.

AU - Boulanger, Lisa M.

PY - 2012/5/24

Y1 - 2012/5/24

N2 - In many parts of the developing vertebrate nervous system, axons are pruned to establish mature patterns of connectivity. In this issue of Neuron, Schafer et al. (2012) show that microglia may play a role in developmental axon pruning in the thalamus by engulfing presynaptic retinal ganglion cell terminals via a C3- and CR3-dependent mechanism.

AB - In many parts of the developing vertebrate nervous system, axons are pruned to establish mature patterns of connectivity. In this issue of Neuron, Schafer et al. (2012) show that microglia may play a role in developmental axon pruning in the thalamus by engulfing presynaptic retinal ganglion cell terminals via a C3- and CR3-dependent mechanism.

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JO - Neuron

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IS - 4

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Complement-Mediated Microglial Clearance of Developing Retinal Ganglion Cell Axons

Abstract

All Science Journal Classification (ASJC) codes

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