Complement-Mediated Microglial Clearance of Developing Retinal Ganglion Cell Axons

Carolyn M. Tyler, Lisa M. Boulanger

Research output: Contribution to journalShort survey

9 Scopus citations

Abstract

In many parts of the developing vertebrate nervous system, axons are pruned to establish mature patterns of connectivity. In this issue of Neuron, Schafer et al. (2012) show that microglia may play a role in developmental axon pruning in the thalamus by engulfing presynaptic retinal ganglion cell terminals via a C3- and CR3-dependent mechanism.

Original languageEnglish (US)
Pages (from-to)597-599
Number of pages3
JournalNeuron
Volume74
Issue number4
DOIs
StatePublished - May 24 2012

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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