Common and unique features of viral RNA-dependent polymerases

Aartjan J.W. Te Velthuis

doi:10.1007/s00018-014-1695-z

Common and unique features of viral RNA-dependent polymerases

Aartjan J.W. Te Velthuis

Research output: Contribution to journal › Review article › peer-review

155 Scopus citations

Abstract

Eukaryotes and bacteria can be infected with a wide variety of RNA viruses. On average, these pathogens share little sequence similarity and use different replication and transcription strategies. Nevertheless, the members of nearly all RNA virus families depend on the activity of a virally encoded RNA-dependent polymerase for the condensation of nucleotide triphosphates. This review provides an overview of our current understanding of the viral RNA-dependent polymerase structure and the biochemistry and biophysics that is involved in replicating and transcribing the genetic material of RNA viruses.

Original language	English (US)
Pages (from-to)	4403-4420
Number of pages	18
Journal	Cellular and Molecular Life Sciences
Volume	71
Issue number	22
DOIs	https://doi.org/10.1007/s00018-014-1695-z
State	Published - Oct 24 2014
Externally published	Yes

All Science Journal Classification (ASJC) codes

Molecular Medicine
Molecular Biology
Pharmacology
Cellular and Molecular Neuroscience
Cell Biology

Keywords

Dynamics
RNA virus
RdRp
Retrovirus
Reverse transcriptase

Access to Document

10.1007/s00018-014-1695-z

Cite this

@article{187d5a42d032450486dc142d14a0c577,

title = "Common and unique features of viral RNA-dependent polymerases",

abstract = "Eukaryotes and bacteria can be infected with a wide variety of RNA viruses. On average, these pathogens share little sequence similarity and use different replication and transcription strategies. Nevertheless, the members of nearly all RNA virus families depend on the activity of a virally encoded RNA-dependent polymerase for the condensation of nucleotide triphosphates. This review provides an overview of our current understanding of the viral RNA-dependent polymerase structure and the biochemistry and biophysics that is involved in replicating and transcribing the genetic material of RNA viruses.",

keywords = "Dynamics, RNA virus, RdRp, Retrovirus, Reverse transcriptase",

author = "{Te Velthuis}, {Aartjan J.W.}",

note = "Funding Information: Apologies to colleagues whose work could not be cited due to length restrictions. This work was supported by Grants 021.001.037 and 825.11.029 from the Netherlands Organization for Scientific Research (NWO), Grant 098721/Z/12/Z from the Wellcome Trust and a Kemp postdoctoral fellowship from Lincoln College Oxford. Dr. Eric Snijder, Dr. Ervin Fodor, and Dr. Frank Vreede are kindly acknowledged for helpful comments and suggestions. Publisher Copyright: {\textcopyright} 2014 The Author(s).",

year = "2014",

month = oct,

day = "24",

doi = "10.1007/s00018-014-1695-z",

language = "English (US)",

volume = "71",

pages = "4403--4420",

journal = "Cellular and Molecular Life Sciences",

issn = "1420-682X",

publisher = "Birkhauser Verlag Basel",

number = "22",

}

TY - JOUR

T1 - Common and unique features of viral RNA-dependent polymerases

AU - Te Velthuis, Aartjan J.W.

N1 - Funding Information: Apologies to colleagues whose work could not be cited due to length restrictions. This work was supported by Grants 021.001.037 and 825.11.029 from the Netherlands Organization for Scientific Research (NWO), Grant 098721/Z/12/Z from the Wellcome Trust and a Kemp postdoctoral fellowship from Lincoln College Oxford. Dr. Eric Snijder, Dr. Ervin Fodor, and Dr. Frank Vreede are kindly acknowledged for helpful comments and suggestions. Publisher Copyright: © 2014 The Author(s).

PY - 2014/10/24

Y1 - 2014/10/24

N2 - Eukaryotes and bacteria can be infected with a wide variety of RNA viruses. On average, these pathogens share little sequence similarity and use different replication and transcription strategies. Nevertheless, the members of nearly all RNA virus families depend on the activity of a virally encoded RNA-dependent polymerase for the condensation of nucleotide triphosphates. This review provides an overview of our current understanding of the viral RNA-dependent polymerase structure and the biochemistry and biophysics that is involved in replicating and transcribing the genetic material of RNA viruses.

AB - Eukaryotes and bacteria can be infected with a wide variety of RNA viruses. On average, these pathogens share little sequence similarity and use different replication and transcription strategies. Nevertheless, the members of nearly all RNA virus families depend on the activity of a virally encoded RNA-dependent polymerase for the condensation of nucleotide triphosphates. This review provides an overview of our current understanding of the viral RNA-dependent polymerase structure and the biochemistry and biophysics that is involved in replicating and transcribing the genetic material of RNA viruses.

KW - Dynamics

KW - RNA virus

KW - RdRp

KW - Retrovirus

KW - Reverse transcriptase

UR - http://www.scopus.com/inward/record.url?scp=84925285590&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84925285590&partnerID=8YFLogxK

U2 - 10.1007/s00018-014-1695-z

DO - 10.1007/s00018-014-1695-z

M3 - Review article

C2 - 25080879

AN - SCOPUS:84925285590

SN - 1420-682X

VL - 71

SP - 4403

EP - 4420

JO - Cellular and Molecular Life Sciences

JF - Cellular and Molecular Life Sciences

IS - 22

ER -

Common and unique features of viral RNA-dependent polymerases

Abstract

All Science Journal Classification (ASJC) codes

Keywords

Access to Document

Other files and links

Fingerprint

Cite this