We introduce a novel framework of Prophet Inequalities for combinatorial valuation functions. For a (non-monotone) submodular objective function over an arbitrary matroid feasibility constraint, we give an O(1)-competitive algorithm. For a monotone subadditive objective function over an arbitrary downwardclosed feasibility constraint, we give an O(log n log2 r) competitive algorithm (where r is the cardinality of the largest feasible subset). Inspired by the proof of our subadditive prophet inequality, we also obtain an O(log n log2 r)-competitive algorithm for the Secretary Problem with a monotone subadditive objective function subject to an arbitrary downward-closed feasibility constraint. Even for the special case of a cardinality feasibility constraint, our algorithm circumvents an ( p n) lower bound by Bateni, Hajiaghayi, and Zadimoghaddam  in a restricted query model. En route to our submodular prophet inequality, we prove a technical result of independent interest: we show a variant of the Correlation Gap Lemma [14, 1] for nonmonotone submodular functions.