Combinatorial generation of droplets by controlled assembly and coalescence

Eujin Um, Matthew E. Rogers, Howard A. Stone

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


We describe a microfluidic system for generating a sequence of liquid droplets of multiple concentrations in a single experimental condition. The series of final droplets has the combination of the compositions varying periodically, with polydispersity of the size less than 8%. By utilizing the design of the microchannel geometry and the passive control of three immiscible fluids (oil, water, and air) including generation, breakup, separation and coalescence of droplets, we can change the system to generate diverse sets of combination of materials. The device can be used for testing different concentration of materials in picoliter volumes and developing a new way to deliver dynamic signals of chemicals with microfluidics.

Original languageEnglish (US)
Pages (from-to)4674-4680
Number of pages7
JournalLab on a Chip
Issue number23
StatePublished - Dec 7 2013

All Science Journal Classification (ASJC) codes

  • General Chemistry
  • Bioengineering
  • Biochemistry
  • Biomedical Engineering


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