@article{836d8c68919f4923ba4d88dd8398fda3,
title = "Collaboration as a Key to Advance Capabilities for Earth-Abundant Metal Catalysis",
abstract = "Earth-abundant metal (EAM) catalysis can have profound impact in the pharmaceutical industry in terms of sustainability and cost improvements from replacing precious metals like palladium as well as harnessing the differential reactivity of first-row metals that allows for novel transformations to enable more efficient routes to clinical candidates. The strategy for building these capabilities within the process group at Bristol Myers Squibb is described herein, with the general plan of building a reaction screening platform, demonstrating scalability, and increasing mechanistic understanding of the reaction and catalyst activation. The development of catalytic transformations utilizing nickel, cobalt, and iron is described while highlighting the importance of collaboration with internal and external groups to advance EAM catalysis and impact our portfolio. The challenges and benefits of working with first-row transition metals, including metrics for the implementation of EAM catalysis, such as cost, process mass intensity, and commercial availability of catalysts and ligands, are discussed.",
keywords = "base metal catalysis, cobalt, cross-coupling, earth-abundant metal catalysis, iron, nickel, sustainability",
author = "Chirik, {Paul J.} and Engle, {Keary M.} and Simmons, {Eric M.} and Wisniewski, {Steven R.}",
note = "Funding Information: We have been extremely fortunate to work with a number of incredibly talented scientists though our partnerships with academic groups, including the graduate students and postdocs in our collaborations with the Chirik and Engle laboratories as well as the graduate and undergraduate students from the Frantz lab who helped us explore palladium- and nickel-catalyzed borylation reactions. We are grateful for the dedication and contributions of the members of the BMS Catalysis Community of Practice who have helped to the build the platforms and mechanistic understandings discussed in this Perspective. We thank Dr. Francisco Gonz{\'a}lez-Bobes, Dr. Martin Eastgate, Dr. Rodney Parsons, and the Chemical Process Development Senior Leadership Team for the continued support of our efforts in earth-abundant metal catalysis and Dr. Matthew Joannou for providing a critical reading of this manuscript. Work on nickel catalysis in the Engle lab at Scripps Research, including the development of bench-stable Ni(0) precatalysts, was supported by BMS and the NSF (CHE1800280 and CHE-2102550). Work on cobalt and iron catalysis in the Chirik lab at Princeton was supported by BMS through the Princeton Catalysis Initiative. Publisher Copyright: {\textcopyright} 2023 American Chemical Society",
year = "2023",
month = jul,
day = "21",
doi = "10.1021/acs.oprd.3c00025",
language = "English (US)",
volume = "27",
pages = "1160--1184",
journal = "Organic Process Research and Development",
issn = "1083-6160",
publisher = "American Chemical Society",
number = "7",
}