Cognitive compromise following exercise in monozygotic twins discordant for chronic fatigue syndrome: Fact or artifact?

Keith Claypoole, Roderick Mahurin, Mary E. Fischer, Jack Goldberg, Karen B. Schmaling, Robert B. Schoene, Suzanne Ashton, Dedra Buchwald

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


This study examined the effects of exhaustive exercise on cognitive functioning among 21 monozygotic twin pairs discordant for chronic fatigue syndrome (CFS). The co-twin control design adjusts for genetic and family environmental factors not generally accounted for in more traditional research designs of neuropsychological function. Participants pedaled a cycle ergometer to exhaustion; maximum oxygen output capacity (VO2 max) as well as perceived exertion were recorded. Neuropsychological tests of brief attention and concentration, speed of visual motor information processing, verbal learning and recognition memory, and word and category fluency were administered with alternate forms to participants pre- and postexercise. The preexercise neuropsychological test performance of CFS twins tended to be slightly below that of the healthy twin controls on all measures. However, twins with CFS did not demonstrate differential decrements in neuropsychological functioning after exercise relative to their healthy co-twins. Because exercise does not appear to diminish cognitive function, rehabilitative treatment approaches incorporating exercise are not contraindicated in CFS.

Original languageEnglish (US)
Pages (from-to)31-40
Number of pages10
JournalApplied Neuropsychology
Issue number1
StatePublished - Jan 1 2001
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuropsychology and Physiological Psychology
  • Developmental and Educational Psychology
  • Arts and Humanities (miscellaneous)


  • Chronic fatigue syndrome
  • Cognition
  • Neuropsychological function
  • Twins

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