Coding potential of laboratory and clinical strains of human cytomegalovirus

Eain Murphy, Dong Yu, Jane Grimwood, Jeremy Schmutz, Mark Dickson, Michael A. Jarvis, Gabriele Hahn, Jay A. Nelson, Richard M. Myers, Thomas E. Shenk

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Abstract

Six strains of human cytomegalovirus have been sequenced, including two laboratory strains (AD169 and Towne) that have been extensively passaged in fibroblasts and four clinical isolates that have been passaged to a limited extent in the laboratory (Toledo, FIX, PH, and TR). All of the sequenced viral genomes have been cloned as infectious bacterial artificial chromosomes. A total of 252 ORFs with the potential to encode proteins have been identified that are conserved in all four clinical isolates of the virus. Multiple sequence alignments revealed substantial variation in the amino acid sequences encoded by many of the conserved ORFs.

Original languageEnglish (US)
Pages (from-to)14976-14981
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume100
Issue number25
DOIs
StatePublished - Dec 9 2003

All Science Journal Classification (ASJC) codes

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    Murphy, E., Yu, D., Grimwood, J., Schmutz, J., Dickson, M., Jarvis, M. A., Hahn, G., Nelson, J. A., Myers, R. M., & Shenk, T. E. (2003). Coding potential of laboratory and clinical strains of human cytomegalovirus. Proceedings of the National Academy of Sciences of the United States of America, 100(25), 14976-14981. https://doi.org/10.1073/pnas.2136652100