@article{0953099f603a4302a70a9c3a0a5e888b,
title = "Cobalt-Catalyzed C(sp2)-C(sp3) Suzuki-Miyaura Cross Coupling",
abstract = "A cobalt-catalyzed method for the C(sp2)-C(sp3) Suzuki-Miyaura cross coupling of aryl boronic esters and alkyl bromides is described. Cobalt-ligand combinations were assayed with high-throughput experimentation, and cobalt(II) sources with trans-N,N′-dimethylcyclohexane-1,2-diamine (DMCyDA, L1) produced optimal yield and selectivity. The scope of this transformation encompassed steric and electronic diversity on the aryl boronate nucleophile as well as various levels of branching and synthetically valuable functionality on the electrophile. Radical trap experiments support the formation of electrophile-derived radicals during catalysis.",
author = "Ludwig, {Jacob R.} and Simmons, {Eric M.} and Wisniewski, {Steven R.} and Chirik, {Paul J.}",
note = "Funding Information: J.R.L. thanks the NIH for a Ruth L. Kirschstein National Research Service Award (F32 GM137552). Sharla Wood (BMS), Ziqing Lin (BMS), and Wei Ding (BMS) are gratefully acknowledged for ICP-MS analysis, LC method development, and HRMS analysis, respectively. Laura Wilson and Brandon Kennedy of Lotus Separations are gratefully acknowledged for the development and implementation of purification protocols in various stages of the project. Financial support from the National Institutes of Health (5R01GM121441) and BMS through the Princeton Catalysis Initiative is acknowledged. We thank Paul O. Peterson, Michael Schmidt, and Gregory Beutner for helpful discussions. Publisher Copyright: {\textcopyright} 2021 American Chemical Society. All rights reserved.",
year = "2021",
month = feb,
day = "5",
doi = "10.1021/acs.orglett.0c02934",
language = "English (US)",
volume = "23",
journal = "Organic letters",
issn = "1523-7060",
publisher = "American Chemical Society",
number = "3",
}