TY - JOUR
T1 - Coat variation in the domestic dog is governed by variants in three genes
AU - Cadieu, Edouard
AU - Neff, Mark W.
AU - Quignon, Pascale
AU - Walsh, Kari
AU - Chase, Kevin
AU - Parker, Heidi G.
AU - vonHoldt, Bridgett Marie
AU - Rhue, Alison
AU - Boyko, Adam B.
AU - Byers, Alexandra
AU - Wong, Aaron
AU - Mosher, Dana S.
AU - Elkahloun, Abdel G.
AU - Spady, Tyrone C.
AU - André, Catherine
AU - Lark, Gordon K.
AU - Cargill, Michelle
AU - Bustamante, Carlos D.
AU - Wayne, Robert K.
AU - Ostrander, Elaine A.
PY - 2009
Y1 - 2009
N2 - Coat color and type are essential characteristics of domestic dog breeds. Although the genetic basis of coat color has been well characterized, relatively little is known about the genes influencing coat growth pattern, length, and curl. We performed genome-wide association studies of more than 1000 dogs from 80 domestic breeds to identify genes associated with canine fur phenotypes. Taking advantage of both inter- and intrabreed variability, we identified distinct mutations in three genes, RSPO2, FGF5, and KRT71 (encoding R-spondin-2, fibroblast growth factor-5, and keratin-71, respectively), that together account for most coat phenotypes in purebred dogs in the United States. Thus, an array of varied and seemingly complex phenotypes can be reduced to the combinatorial effects of only a few genes.
AB - Coat color and type are essential characteristics of domestic dog breeds. Although the genetic basis of coat color has been well characterized, relatively little is known about the genes influencing coat growth pattern, length, and curl. We performed genome-wide association studies of more than 1000 dogs from 80 domestic breeds to identify genes associated with canine fur phenotypes. Taking advantage of both inter- and intrabreed variability, we identified distinct mutations in three genes, RSPO2, FGF5, and KRT71 (encoding R-spondin-2, fibroblast growth factor-5, and keratin-71, respectively), that together account for most coat phenotypes in purebred dogs in the United States. Thus, an array of varied and seemingly complex phenotypes can be reduced to the combinatorial effects of only a few genes.
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U2 - 10.1126/science.1177808
DO - 10.1126/science.1177808
M3 - Article
C2 - 19713490
AN - SCOPUS:70349675731
SN - 0036-8075
VL - 326
SP - 150
EP - 153
JO - Science
JF - Science
IS - 5949
ER -