CMOS-NANOWELL BASED HYBRID SMART BANDAGE FOR LONG TERM MONITORING OF WOUND HEALING VIA CYTOKINE QUANTIFICATION IN-SITU

Chengjie Zhu, Pengfei Xie, Ryan Thorpe, Jesus Maldonado, Suneel Kumar, Aaron Mazzeo, Mehdi Javanmard, Francois Berthiaume, Kaushik Sengupta

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Long-term monitoring of the chronic wound can allow autonomous wound healing. Prior attempts that sense wound closure dynamics in bandage forms are based on pressure, temperature and pH, lacking specific bio-molecular information that is critical for accurate acquisition of growth factors in various wound healing stages. This work presents a hybrid CMOS/nanowell co-design approach to target cytokine level to predict wound closure dynamics. The complete impedance spectroscopy chip is designed and fabricated in TSMC 65 nm LP process and is integrated on a flexible PCB compatible to "Smart Bandage"forms along with nanowell sensors located at the back and peripheral circuits. The proposed system demonstrates the sensitivity of IL-6 cytokine on the order of 100 pg/mL, and shows strong correlations to the standardized ELISA tests. This proposed CMOS/nano hybrid approach shows a path towards highly multiplexed and low-cost "Smart Bandages"for autonomous closed-loop wound monitoring and healing applications.

Original languageEnglish (US)
Title of host publication2022 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2022
EditorsReza Ghodssi, Jenna F. Chan
PublisherTransducer Research Foundation
Pages122-125
Number of pages4
ISBN (Electronic)9781940470047
StatePublished - 2022
Event2022 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2022 - Hilton Head, United States
Duration: Jun 5 2022Jun 9 2022

Publication series

Name2022 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2022

Conference

Conference2022 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2022
Country/TerritoryUnited States
CityHilton Head
Period6/5/226/9/22

All Science Journal Classification (ASJC) codes

  • Hardware and Architecture
  • Electrical and Electronic Engineering

Keywords

  • cytokine
  • ELISA
  • impedance spectroscopy
  • nano-fabrication
  • Smart bandages
  • wound healing

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