CMOS-Driven Pneumatic-Free Scalable Microfluidics and Fluid Processing with Label-Free Cellular and Bio-Molecular Sensing Capability for an End-to-End Point-of-Care System

Chengjie Zhu, Jesus Maldonado, Hao Tang, Suresh Venkatesh, Kaushik Sengupta

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The emergence of the pandemic has demonstrated the necessity of point-of-care (POC) molecular diagnostic platforms that encompass an end-to-end system (from sample fluid to diagnostic information) with the ability to allow rapid analysis on the spot. While POC sensing technologies have been demonstrated in miniaturize chip-scale platforms [1-5], the bottlenecks in enabling end-to-end low-cost handheld platforms have often been bio-sample handling, filtering, mixing with re-agents that are critical to the robustness of the assay chemistry and sensing sensitivity/specificity. These processes are typically carried out either manually or by employing complex pneumatic flow control with multiple bulky syringe pumps, which have been a severe limitation to enable end-to-end biosensing systems (Fig. 18.2.1). While electrically driven droplets, molecular and cell manipulation techniques, such as electro-wetting, electrophoresis and dielectrophoresis, have been demonstrated in singular systems before [1], they do not have the ability to process bulk bio-sample fluids that is required for POC devices. In this paper, we present a scalable approach that merges the functionalities of sample processing and cellular/bio-molecular sensing in a single system and eliminates any pneumatic pumping mechanisms by exploiting CMOS-based electrically driven electro-kinetic flow of bulk fluids. We demonstrate, for the first time, a CMOS-microfluidic system that is capable of 1) pumping bulk electrolyte fluid with AC electro-osmosis, 2) cell manipulation and separation with dielectrophoresis (DEP), 3) label-free biomolecular and cell sensing, classification with dedicated 16-element impedance spectroscopy receivers. While we demonstrate these kernel functionalities in a multichip module/microfluidic interface (Fig. 18.2.1), the overall architecture, fluidics and sensing components can be massively scaled up for various POC applications due to elimination of pressure-driven flows (Fig. 18.2.1).

Original languageEnglish (US)
Title of host publication2021 IEEE International Solid-State Circuits Conference, ISSCC 2021 - Digest of Technical Papers
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages278-280
Number of pages3
ISBN (Electronic)9781728195490
DOIs
StatePublished - Feb 13 2021
Event2021 IEEE International Solid-State Circuits Conference, ISSCC 2021 - San Francisco, United States
Duration: Feb 13 2021Feb 22 2021

Publication series

NameDigest of Technical Papers - IEEE International Solid-State Circuits Conference
Volume64
ISSN (Print)0193-6530

Conference

Conference2021 IEEE International Solid-State Circuits Conference, ISSCC 2021
CountryUnited States
CitySan Francisco
Period2/13/212/22/21

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Electrical and Electronic Engineering

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