Click Chemistry in Protein Engineering, Design, Detection and Profiling

Daniela C. Dieterich, A. James Link

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations
Original languageEnglish (US)
Title of host publicationClick Chemistry for Biotechnology and Materials Science
PublisherJohn Wiley and Sons
Number of pages17
ISBN (Print)9780470699706
StatePublished - Oct 20 2009

All Science Journal Classification (ASJC) codes

  • General Materials Science


  • BONCAT (bio-orthogonal noncanonical amino acid tagging)
  • Click chemistry in protein engineering, design, detection and profiling
  • Click chemistry reaction, CuAAC and protein conjugation and proteomic advancement
  • Cotranslational functionalization of proteins with azides and alkynes
  • CuAAC for bioconjugation and labeled cowpea mosaic virus (CPMV) particles
  • CuAAC specificity and 'bioorthogonality'
  • Expressed protein ligation strategy and E. coli maltose-binding protein (MBP)
  • Language of proteins - set of 20 canonical amino acids and protein structures and functions
  • Residue-specific incorporation technique
  • TBTA ligand improving kinetics of CuAAC bioconjugations


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