@article{ead13bb920c04530be03cdb177f2ab46,
title = "Classical carbonyl reactivity enables a short synthesis of the core structure of acutumine",
abstract = "The development of a direct synthesis of the complex core topology of the alkaloid acutumine from a simple keto proline derivative is described. An efficient sequence of three carbonyl-dependent reactions is at the heart of this design for synthesis.",
keywords = "Acutumine, Chlorine-containing alkaloids, Dieckmann condensation, Michael reaction, The carbonyl group, β-Elimination",
author = "Moreau, {Robert J.} and Sorensen, {Erik J.}",
note = "Funding Information: This work was supported by the National Institute of General Medical Sciences (GM074763), Merck Research Laboratories, Boehringer Ingelheim, a Johnson & Johnson Focused Giving Award (E.J.S.), Princeton University, and a predoctoral fellowship from Bristol-Myers Squibb (R.J.M.). We thank Dr. G{\"u}nther Scheid for his early efforts on this project, particularly on the quinone-based route. We also thank Dr. Istv{\'a}n Pelczer and Dr. Carlos Pacheco (Princeton) for NMR assistance, and Dr. Gary Siuzdak (The Scripps Research Institute) for mass spectral analysis. ",
year = "2007",
month = jul,
day = "9",
doi = "10.1016/j.tet.2007.03.024",
language = "English (US)",
volume = "63",
pages = "6446--6453",
journal = "Tetrahedron",
issn = "0040-4020",
publisher = "Elsevier Ltd",
number = "28",
}