Abstract
The development of a direct synthesis of the complex core topology of the alkaloid acutumine from a simple keto proline derivative is described. An efficient sequence of three carbonyl-dependent reactions is at the heart of this design for synthesis.
Original language | English (US) |
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Pages (from-to) | 6446-6453 |
Number of pages | 8 |
Journal | Tetrahedron |
Volume | 63 |
Issue number | 28 |
DOIs | |
State | Published - Jul 9 2007 |
All Science Journal Classification (ASJC) codes
- Biochemistry
- Drug Discovery
- Organic Chemistry
Keywords
- Acutumine
- Chlorine-containing alkaloids
- Dieckmann condensation
- Michael reaction
- The carbonyl group
- β-Elimination