Abstract
Hippocampal cell proliferation and concomitant motor activity were examined in adult male mice (C57BL/6J) across a 12:12 h light-dark cycle. 5-Bromo-2′-deoxyuridine (BrdU) (200 mg/kg, i.p.) was administered at six equally spaced time points across 24 h. A significant change in cell proliferation was found in the hilus (light phase > dark phase), but not in the granule cell layer (GCL)/subgranular zone (SGZ). Since it is generally believed that proliferating cells in the hilus and GCL/SGZ give rise primarily to glia and neurons, respectively, these data suggest a possible circadian influence on gliogenesis, rather than neurogenesis.
Original language | English (US) |
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Pages (from-to) | 256-259 |
Number of pages | 4 |
Journal | Neuroscience Letters |
Volume | 406 |
Issue number | 3 |
DOIs | |
State | Published - Oct 9 2006 |
All Science Journal Classification (ASJC) codes
- General Neuroscience
Keywords
- BrdU
- Circadian rhythm
- Dentate gyrus
- Gliogenesis
- Hilus
- Neurogenesis