Circadian variation in mouse hippocampal cell proliferation

Linda J. Kochman, E. Todd Weber, Casimir A. Fornal, Barry L. Jacobs

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


Hippocampal cell proliferation and concomitant motor activity were examined in adult male mice (C57BL/6J) across a 12:12 h light-dark cycle. 5-Bromo-2′-deoxyuridine (BrdU) (200 mg/kg, i.p.) was administered at six equally spaced time points across 24 h. A significant change in cell proliferation was found in the hilus (light phase > dark phase), but not in the granule cell layer (GCL)/subgranular zone (SGZ). Since it is generally believed that proliferating cells in the hilus and GCL/SGZ give rise primarily to glia and neurons, respectively, these data suggest a possible circadian influence on gliogenesis, rather than neurogenesis.

Original languageEnglish (US)
Pages (from-to)256-259
Number of pages4
JournalNeuroscience Letters
Issue number3
StatePublished - Oct 9 2006

All Science Journal Classification (ASJC) codes

  • General Neuroscience


  • BrdU
  • Circadian rhythm
  • Dentate gyrus
  • Gliogenesis
  • Hilus
  • Neurogenesis


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