Chronic amphetamine administration decreases brain tryptophan hydroxylase activity in cats

Michael E. Trulson; Barry L. Jacobs

doi:10.1016/0024-3205(80)90148-4

Chronic amphetamine administration decreases brain tryptophan hydroxylase activity in cats

Michael E. Trulson, Barry L. Jacobs

Psychology

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Chronic administration of d-amphetamine sulfate (7.5 mg/kg, i.p. every 12 hrs. for 6 days) to cats produced significant decreases in the Vmax of brain-stem and forebrain tryptophan hydroxylase when measured 1 day (-34 and -46%) and 10 days (-17 and -30%) after the final amphetamine injection. Serotonin and 5-hydroxyindoleacetic acid (5HIAA) levels were decreased by a similar magnitude. A single injection of amphetamine (7.5 mg/kg) produced no significant changes in tryptophan hydroxylase activity, serotonin, or 5HIAA when measured 1 day after the injection. Neither acute nor chronic amphetamine treatment produced any significant changes in the Km of tryptophan hydroxylase for either tryptophan or the natural co-factor, tetrahydrobiopterin. These data suggest that chronic amphetamine treatment decreases central serotonergic neurotransmission by an action on the rate-limiting enzyme in serotonin biosynthesis.

Original language	English (US)
Pages (from-to)	329-335
Number of pages	7
Journal	Life Sciences
Volume	26
Issue number	5
DOIs	https://doi.org/10.1016/0024-3205(80)90148-4
State	Published - Feb 4 1980

All Science Journal Classification (ASJC) codes

General Pharmacology, Toxicology and Pharmaceutics
General Biochemistry, Genetics and Molecular Biology

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10.1016/0024-3205(80)90148-4

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title = "Chronic amphetamine administration decreases brain tryptophan hydroxylase activity in cats",

abstract = "Chronic administration of d-amphetamine sulfate (7.5 mg/kg, i.p. every 12 hrs. for 6 days) to cats produced significant decreases in the Vmax of brain-stem and forebrain tryptophan hydroxylase when measured 1 day (-34 and -46%) and 10 days (-17 and -30%) after the final amphetamine injection. Serotonin and 5-hydroxyindoleacetic acid (5HIAA) levels were decreased by a similar magnitude. A single injection of amphetamine (7.5 mg/kg) produced no significant changes in tryptophan hydroxylase activity, serotonin, or 5HIAA when measured 1 day after the injection. Neither acute nor chronic amphetamine treatment produced any significant changes in the Km of tryptophan hydroxylase for either tryptophan or the natural co-factor, tetrahydrobiopterin. These data suggest that chronic amphetamine treatment decreases central serotonergic neurotransmission by an action on the rate-limiting enzyme in serotonin biosynthesis.",

author = "Trulson, {Michael E.} and Jacobs, {Barry L.}",

note = "Funding Information: This research was supported by National Institute of Mental Health Grant MH23433, the Alfred P. Sloan Foundation, and the Scottish Rite Schizophrenia Research Program, N.M.J., U.S .A . We thank Ren{\'e}e M . Paternoster for excellent technical assistance .",

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doi = "10.1016/0024-3205(80)90148-4",

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T1 - Chronic amphetamine administration decreases brain tryptophan hydroxylase activity in cats

AU - Trulson, Michael E.

AU - Jacobs, Barry L.

N1 - Funding Information: This research was supported by National Institute of Mental Health Grant MH23433, the Alfred P. Sloan Foundation, and the Scottish Rite Schizophrenia Research Program, N.M.J., U.S .A . We thank Renée M . Paternoster for excellent technical assistance .

PY - 1980/2/4

Y1 - 1980/2/4

N2 - Chronic administration of d-amphetamine sulfate (7.5 mg/kg, i.p. every 12 hrs. for 6 days) to cats produced significant decreases in the Vmax of brain-stem and forebrain tryptophan hydroxylase when measured 1 day (-34 and -46%) and 10 days (-17 and -30%) after the final amphetamine injection. Serotonin and 5-hydroxyindoleacetic acid (5HIAA) levels were decreased by a similar magnitude. A single injection of amphetamine (7.5 mg/kg) produced no significant changes in tryptophan hydroxylase activity, serotonin, or 5HIAA when measured 1 day after the injection. Neither acute nor chronic amphetamine treatment produced any significant changes in the Km of tryptophan hydroxylase for either tryptophan or the natural co-factor, tetrahydrobiopterin. These data suggest that chronic amphetamine treatment decreases central serotonergic neurotransmission by an action on the rate-limiting enzyme in serotonin biosynthesis.

AB - Chronic administration of d-amphetamine sulfate (7.5 mg/kg, i.p. every 12 hrs. for 6 days) to cats produced significant decreases in the Vmax of brain-stem and forebrain tryptophan hydroxylase when measured 1 day (-34 and -46%) and 10 days (-17 and -30%) after the final amphetamine injection. Serotonin and 5-hydroxyindoleacetic acid (5HIAA) levels were decreased by a similar magnitude. A single injection of amphetamine (7.5 mg/kg) produced no significant changes in tryptophan hydroxylase activity, serotonin, or 5HIAA when measured 1 day after the injection. Neither acute nor chronic amphetamine treatment produced any significant changes in the Km of tryptophan hydroxylase for either tryptophan or the natural co-factor, tetrahydrobiopterin. These data suggest that chronic amphetamine treatment decreases central serotonergic neurotransmission by an action on the rate-limiting enzyme in serotonin biosynthesis.

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Chronic amphetamine administration decreases brain tryptophan hydroxylase activity in cats

Abstract

All Science Journal Classification (ASJC) codes

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