Chemosensing in Escherichia coli: Two regimes of two-state receptors

Juan E. Keymer, Robert G. Endres, Monica Skoge, Yigal Meir, Ned S. Wingreen

Research output: Contribution to journalArticlepeer-review

147 Scopus citations

Abstract

The chemotaxis network in Escherichia coli is remarkable for its sensitivity to small relative changes in the concentrations of multiple chemical signals. We present a model for signal integration by mixed clusters of interacting two-state chemoreceptors. Our model results compare favorably to the results obtained by Sourjik and Berg with in vivo fluorescence resonance energy transfer. Importantly, we identify two distinct regimes of behavior, depending on the relative energies of the two states of the receptors. In regime I, coupling of receptors leads to high sensitivity, while in regime II, coupling of receptors leads to high cooperatively, i.e., high Hill coefficient. For homogeneous receptors, we predict an observable transition between regime I and regime II with increasing receptor methylation or amidation.

Original languageEnglish (US)
Pages (from-to)1786-1791
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume103
Issue number6
DOIs
StatePublished - Feb 15 2006

All Science Journal Classification (ASJC) codes

  • General

Keywords

  • Chemotaxis
  • Monod, Wyman, and Changeux model
  • Receptor clustering

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