Chemoselective backbone cyclization of unprotected peptides

Julio A. Camarero, Tom W. Muir

Research output: Contribution to journalArticlepeer-review

100 Scopus citations


A fully unprotected 15 residue peptide containing an N-terminal Cys residue and a C-terminal thioester moiety is cleanly converted to the corresponding head-to-tail cyclic peptide in aqueous buffers at around neutral pH.

Original languageEnglish (US)
Pages (from-to)1369-1370
Number of pages2
JournalChemical Communications
Issue number15
StatePublished - 1997
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • General Chemistry
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry


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