Chemoselective backbone cyclization of unprotected peptides

Julio A. Camarero; Tom W. Muir

doi:10.1039/a702083j

Chemoselective backbone cyclization of unprotected peptides

Julio A. Camarero, Tom W. Muir

Research output: Contribution to journal › Article › peer-review

100 Scopus citations

Abstract

A fully unprotected 15 residue peptide containing an N-terminal Cys residue and a C-terminal thioester moiety is cleanly converted to the corresponding head-to-tail cyclic peptide in aqueous buffers at around neutral pH.

Original language	English (US)
Pages (from-to)	1369-1370
Number of pages	2
Journal	Chemical Communications
Issue number	15
DOIs	https://doi.org/10.1039/a702083j
State	Published - 1997
Externally published	Yes

All Science Journal Classification (ASJC) codes

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/a702083j

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title = "Chemoselective backbone cyclization of unprotected peptides",

abstract = "A fully unprotected 15 residue peptide containing an N-terminal Cys residue and a C-terminal thioester moiety is cleanly converted to the corresponding head-to-tail cyclic peptide in aqueous buffers at around neutral pH.",

author = "Camarero, {Julio A.} and Muir, {Tom W.}",

year = "1997",

doi = "10.1039/a702083j",

language = "English (US)",

pages = "1369--1370",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

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T1 - Chemoselective backbone cyclization of unprotected peptides

AU - Camarero, Julio A.

AU - Muir, Tom W.

PY - 1997

Y1 - 1997

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U2 - 10.1039/a702083j

DO - 10.1039/a702083j

M3 - Article

AN - SCOPUS:1542468131

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SP - 1369

EP - 1370

JO - Chemical Communications

JF - Chemical Communications

IS - 15

ER -

Chemoselective backbone cyclization of unprotected peptides

Abstract

All Science Journal Classification (ASJC) codes

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