Chemical sensing by nonequilibrium cooperative receptors

Monica Skoge, Sahin Naqvi, Yigal Meir, Ned S. Wingreen

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Cooperativity arising from local interactions in equilibrium receptor systems provides gain, but does not increase sensory performance, as measured by the signal-to-noise ratio (SNR) due to a fundamental tradeoff between gain and intrinsic noise. Here we allow sensing to be a nonequilibrium process and show that energy dissipation cannot circumvent the fundamental tradeoff, so that the SNR is still optimal for independent receptors. For systems requiring high gain, nonequilibrium 2D-coupled receptors maximize the SNR, revealing a new design principle for biological sensors.

Original languageEnglish (US)
Article number248102
JournalPhysical review letters
Volume110
Issue number24
DOIs
StatePublished - Jun 11 2013

All Science Journal Classification (ASJC) codes

  • Physics and Astronomy(all)

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