Characterization of the adenovirus 2 virion protein, Mu

Carl W. Anderson, Marjorie E. Young, S. J. Flint

Research output: Contribution to journalArticlepeer-review

60 Scopus citations

Abstract

Adenovirus 2 virions contain a small, highly basic protein known as μ (mu). Partial sequence analysis of mu labeled with radioactive amino acids showed that it is derived from an 11-kDa virion precursor protein, L2-79R. Amino acid analysis, direct microsequence analysis, time-of-flight mass spectrometer analysis, and chemical synthesis demonstrated that mu is the unmodified, 19 amino acid peptide obtained from the 79-residue precursor by adenovirus-encoded proteinase-mediated cleavage after glycine31 and glycine50. Mu bound tightly to DNA and was located in the virion core. In vitro, mu could precipitate DNA fragments, suggesting that it may have a role in viral chromosome condensation.

Original languageEnglish (US)
Pages (from-to)506-512
Number of pages7
JournalVirology
Volume172
Issue number2
DOIs
StatePublished - Oct 1989

All Science Journal Classification (ASJC) codes

  • Virology

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