Characterization of integrated Moloney sarcoma proviruses and flanking host sequences cloned in bacteriophage λ

G. F. Vande Woude; M. Oskarsson; W. L. McClements; L. W. Enquist; D. G. Blair; P. J. Fischinger; J. V. Maizel; M. Sullivan

Characterization of integrated Moloney sarcoma proviruses and flanking host sequences cloned in bacteriophage λ

G. F. Vande Woude, M. Oskarsson, W. L. McClements, L. W. Enquist, D. G. Blair, P. J. Fischinger, J. V. Maizel, M. Sullivan

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14 Scopus citations

Abstract

It is now feasible, through use of recombinant DNA technology, to perform direct genomic comparisons between MSV isolates. We have cloned the integrated proviral DNA sequences of two MSV isolates, m1 and HT1 in bacteriophage λ. Both cloned fragments isolated from transformed mink cells possess full copies of the sarcoma viruses along with flanking host sequences. These cloned fragments have provided the means for direct comparison of the MSV isolates, information on the integration of MSV, and a method of identifying the regions of the viral genome possessing full transforming potential in tissue culture.

Original language	English (US)
Pages (from-to)	735-745
Number of pages	11
Journal	Symposia on Quantitative Biology
Volume	44
Issue number	2
State	Published - 1979

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology
Genetics

Cite this

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title = "Characterization of integrated Moloney sarcoma proviruses and flanking host sequences cloned in bacteriophage λ",

abstract = "It is now feasible, through use of recombinant DNA technology, to perform direct genomic comparisons between MSV isolates. We have cloned the integrated proviral DNA sequences of two MSV isolates, m1 and HT1 in bacteriophage λ. Both cloned fragments isolated from transformed mink cells possess full copies of the sarcoma viruses along with flanking host sequences. These cloned fragments have provided the means for direct comparison of the MSV isolates, information on the integration of MSV, and a method of identifying the regions of the viral genome possessing full transforming potential in tissue culture.",

author = "{Vande Woude}, {G. F.} and M. Oskarsson and McClements, {W. L.} and Enquist, {L. W.} and Blair, {D. G.} and Fischinger, {P. J.} and Maizel, {J. V.} and M. Sullivan",

year = "1979",

language = "English (US)",

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pages = "735--745",

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T1 - Characterization of integrated Moloney sarcoma proviruses and flanking host sequences cloned in bacteriophage λ

AU - Vande Woude, G. F.

AU - Oskarsson, M.

AU - McClements, W. L.

AU - Enquist, L. W.

AU - Blair, D. G.

AU - Fischinger, P. J.

AU - Maizel, J. V.

AU - Sullivan, M.

PY - 1979

Y1 - 1979

N2 - It is now feasible, through use of recombinant DNA technology, to perform direct genomic comparisons between MSV isolates. We have cloned the integrated proviral DNA sequences of two MSV isolates, m1 and HT1 in bacteriophage λ. Both cloned fragments isolated from transformed mink cells possess full copies of the sarcoma viruses along with flanking host sequences. These cloned fragments have provided the means for direct comparison of the MSV isolates, information on the integration of MSV, and a method of identifying the regions of the viral genome possessing full transforming potential in tissue culture.

AB - It is now feasible, through use of recombinant DNA technology, to perform direct genomic comparisons between MSV isolates. We have cloned the integrated proviral DNA sequences of two MSV isolates, m1 and HT1 in bacteriophage λ. Both cloned fragments isolated from transformed mink cells possess full copies of the sarcoma viruses along with flanking host sequences. These cloned fragments have provided the means for direct comparison of the MSV isolates, information on the integration of MSV, and a method of identifying the regions of the viral genome possessing full transforming potential in tissue culture.

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AN - SCOPUS:0018686083

SN - 0091-7451

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EP - 745

JO - Symposia on Quantitative Biology

JF - Symposia on Quantitative Biology

IS - 2

ER -

Characterization of integrated Moloney sarcoma proviruses and flanking host sequences cloned in bacteriophage λ

Abstract

All Science Journal Classification (ASJC) codes

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