Challenges in Antibiotic R&D Calling for a Global Strategy Considering Both Short- And Long-Term Solutions

Cecilia Kållberg, Hege Salvesen Blix, Ramanan Laxminarayan

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

A recent analysis of antibiotics approved between 1999 and 2014, conducted by researchers at the Norwegian Institute of Public Health; the University of Oslo; the Center for Disease Dynamics, Economics & Policy (CDDEP); and Boston University, showed a lack of novelty and diversity regarding target pathogens and indications and a failure to address the most urgent resistance threats, including resistant Gram-negative bacteria. A global research and development strategy should incentivize development of broad-spectrum antibiotics for critically ill patients, as well as therapeutic alternatives to antibiotics, decreasing our dependence on traditional, small-molecule antibiotics.

Original languageEnglish (US)
Pages (from-to)1265-1268
Number of pages4
JournalACS Infectious Diseases
Volume5
Issue number8
DOIs
StatePublished - Aug 9 2019

All Science Journal Classification (ASJC) codes

  • Infectious Diseases

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