Cerebral interneurons controlling fictive feeding in Limax maximus - II. Initiation and modulation of fictive feeding

K. Delaney, A. Gelperin

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

Initiation and modulation of fictive feeding by cerebral to buccal interneurons (CBs) was examined in an isolated CNS preparation of Limax maximus. Three CBs which are phasically active during fictive feeding, CB1, CB3 and CB4, will reliably trigger bouts of fictive feeding when activated alone or in pairs. Another phasic CB, CBEC, is not effective for triggering feeding. One CB which is tonically active during fictive feeding, CBST, drives fictive feeding in 50% of preparations when activated alone and enhances triggering of feeding when co-activated with phasic CBs. The metacerebral giant cell (MGC) was found to be capable of triggering fictive feeding in preparations with an intact subcerebral commissure. The MGC was especially effective at increasing the effectiveness of other CBs for initiation of feeding. Short high-frequency bursts of phasic CB or MGC action potentials are capable of resetting ongoing fictive feeding. Resetting effects of CB action potentials are relatively independent of the phase of the bite-cycle in which they are activated. CB4 phase-advances the bite-cycle while the other phasic CBs phase-delay the bite cycle. Moderate frequency stimulation of CB4 speeds up the bite rate while moderate frequency stimulation of CB3 slows biting. All CBs, except the tonic CB, CBDL, increase the intensity of buccal motor neuron bursting during feeding. The excitatory effects of phasic CBs and the tonic CB, CBEPSP, on fictive feeding persist for many seconds after the offset of stimulation. CBs form both monosynaptic excitatory and monosynaptic inhibitory connections with different BG motor neurons.

Original languageEnglish (US)
Pages (from-to)311-326
Number of pages16
JournalJournal of Comparative Physiology A
Volume166
Issue number3
DOIs
StatePublished - Feb 1 1990
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Ecology, Evolution, Behavior and Systematics
  • Physiology
  • Animal Science and Zoology
  • Behavioral Neuroscience

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