@article{a83d2496cbad43d09d23a775cc4c2500,
title = "Cerebellar involvement in an evidence-accumulation decision-making task",
abstract = "To make successful evidence-based decisions, the brain must rapidly and accurately transform sensory inputs into specific goal-directed behaviors. Most experimental work on this subject has focused on forebrain mechanisms. Using a novel evidence-accumulation task for mice, we performed recording and perturbation studies of crus I of the lateral posterior cerebellum, which communicates bidirectionally with numerous forebrain regions. Cerebellar inactivation led to a reduction in the fraction of correct trials. Using two-photon fluorescence imaging of calcium, we found that Purkinje cell somatic activity contained choice/evidence-related information. Decision errors were represented by dendritic calcium spikes, which in other contexts are known to drive cerebellar plasticity. We propose that cerebellar circuitry may contribute to computations that support accurate performance in this perceptual decision-making task.",
author = "Ben Deverett and Koay, {Sue Ann} and Marlies Oostland and Wang, {Samuel S.H.}",
note = "Funding Information: We thank the members of the laboratories of SW, David Tank, Ilana Witten, and Carlos Brody for discussion and technical assistance, as well as David Tank for advice and support, Esteban Engel for viruses, Ben Scott, Ilana Witten, Carlos Brody, Sandra Aamodt, and Alex Riordan for comments on the manuscript, Stephan Thiberge for microscopy, Steve Lowe for machine shop assistance, Jess Ver-peut and Tom Pisano for technical help, and Sarah Welsh for data analysis. Funded by National Institutes of Health grants R01 NS045193, U01 NS090541, U19 NS104648, R01 MH115750, and F30 MH115577, and the Nancy Lurie Marks Family Foundation. Funding Information: We thank the members of the laboratories of SW, David Tank, Ilana Witten, and Carlos Brody for discussion and technical assistance, as well as David Tank for advice and support, Esteban Engel for viruses, Ben Scott, Ilana Witten, Carlos Brody, Sandra Aamodt, and Alex Riordan for comments onthe manuscript, Stephan Thiberge for microscopy, Steve Lowe for machine shop assistance, Jess Verpeut and Tom Pisano for technical help, and Sarah Welsh for data analysis. Funded by National Institutes of Health grants R01 NS045193, U01 NS090541, U19 NS104648, R01 MH115750, and F30 MH115577, and the Nancy Lurie Marks Family Foundation. National Institute of Mental Health MH115577 Ben Deverett National Institute of Neurological Disorders and Stroke NS090541 Ben Deverett Sue Ann Koay Samuel S-H Wang National Institute of Neurological Disorders and Stroke NS104648 Ben Deverett Sue Ann Koay Samuel S-H Wang Marlies Oostland National Institute of Mental Health MH115750 Samuel S-H Wang Marlies Oostland National Institute of Neurological Disorders and Stroke NS045193 Samuel S-H Wang Nancy Lurie Marks Family Foundation Samuel S-H Wang. Publisher Copyright: {\textcopyright} Deverett et al.",
year = "2018",
month = aug,
day = "13",
doi = "10.7554/eLife.36781",
language = "English (US)",
volume = "7",
journal = "eLife",
issn = "2050-084X",
publisher = "eLife Sciences Publications",
}