Cerebellar disruption impairs working memory during evidence accumulation

Ben Deverett, Mikhail Kislin, David W. Tank, Samuel Sheng-Hung Wang

Research output: Contribution to journalArticle

Abstract

To select actions based on sensory evidence, animals must create and manipulate representations of stimulus information in memory. Here we report that during accumulation of somatosensory evidence, optogenetic manipulation of cerebellar Purkinje cells reduces the accuracy of subsequent memory-guided decisions and causes mice to downweight prior information. Behavioral deficits are consistent with the addition of noise and leak to the evidence accumulation process. We conclude that the cerebellum can influence the accurate maintenance of working memory.

Original languageEnglish (US)
Article number3128
JournalNature communications
Volume10
Issue number1
DOIs
StatePublished - Dec 1 2019

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Short-Term Memory
Optogenetics
Data storage equipment
Purkinje Cells
cerebellum
Cerebellum
Noise
Maintenance
stimuli
maintenance
mice
animals
manipulators
Animals
causes
cells

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

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Cerebellar disruption impairs working memory during evidence accumulation. / Deverett, Ben; Kislin, Mikhail; Tank, David W.; Wang, Samuel Sheng-Hung.

In: Nature communications, Vol. 10, No. 1, 3128, 01.12.2019.

Research output: Contribution to journalArticle

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