Celsr1 coordinates the planar polarity of vestibular hair cells during inner ear development

Jeremy S. Duncan, Michelle L. Stoller, Andrew F. Francl, Fadel Tissir, Danelle Devenport, Michael R. Deans

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Vestibular hair cells of the inner ear are specialized receptors that detect mechanical stimuli from gravity and motion via the deflection of a polarized bundle of stereocilia located on their apical cell surfaces. The orientation of stereociliary bundles is coordinated between neighboring cells by core PCP proteins including the large adhesive G-protein coupled receptor Celsr1. We show that mice lacking Celsr1 have vestibular behavioral phenotypes including circling. In addition, we show that Celsr1 is asymmetrically distributed at cell boundaries between hair cells and neighboring supporting cells in the developing vestibular and auditory sensory epithelia. In the absence of Celsr1 the stereociliary bundles of vestibular hair cells are misoriented relative to their neighbors, a phenotype that is greatest in the cristae of the semicircular canals. Since horizontal semi-circular canal defects lead to circling in other mutant mouse lines, we propose that this PCP phenotype is the cellular basis of the circling behavior in Celsr1 mutants.

Original languageEnglish (US)
Pages (from-to)126-137
Number of pages12
JournalDevelopmental biology
Volume423
Issue number2
DOIs
StatePublished - Mar 15 2017

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Celsr1 coordinates the planar polarity of vestibular hair cells during inner ear development'. Together they form a unique fingerprint.

  • Cite this