Cell fusion hypothesis of the cancer stem cell

Xin Lu, Yibin Kang

Research output: Chapter in Book/Report/Conference proceedingChapter

28 Scopus citations

Abstract

A major advance in recent cancer research is the identification of tumor cells with stem cell-like properties. Cancer stem cells (CSCs) often represent a rare population in the tumor mass and possess the exclusive ability to initiate the growth of a heterogeneous tumor. The origin of CSCs remains elusive and is likely to be cancer type specific. One possible but under-appreciated potential mechanism for the generation of CSCs is through fusion between stem cells and differentiated cells. The cell fusion hypothesis of CSCs adds an important functional underpinning to the potential multifaceted roles of cell fusion in the initiation and progression of cancer.

Original languageEnglish (US)
Title of host publicationCell Fusion in Health and Disease
Subtitle of host publicationII: Cell Fusion in Disease
EditorsThomas Dittmar, Kurt S. Zanker
Pages129-140
Number of pages12
DOIs
StatePublished - Aug 3 2011

Publication series

NameAdvances in Experimental Medicine and Biology
Volume950
ISSN (Print)0065-2598

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Lu, X., & Kang, Y. (2011). Cell fusion hypothesis of the cancer stem cell. In T. Dittmar, & K. S. Zanker (Eds.), Cell Fusion in Health and Disease: II: Cell Fusion in Disease (pp. 129-140). (Advances in Experimental Medicine and Biology; Vol. 950). https://doi.org/10.1007/978-94-007-0782-5_6