Cell fusion as a hidden force in tumor progression

Xin Lu, Yibin Kang

Research output: Contribution to journalReview articlepeer-review

178 Scopus citations


Cell fusion plays an essential role in fertilization, formation of placenta, bone and muscle tissues, immune response, tissue repair, and regeneration. Increasing recognition of cell fusion in somatic cell dynamics has revitalized the century-old hypothesis that cell fusion may contribute to the initiation and progression of cancer. In this review, we discuss findings from experimental and clinical studies that suggest a potentially multifaceted involvement of cell fusion in different stages of tumor progression, including aneuploidy and tumor initiation, origin of cancer stem cells, multidrug resistance, and the acquisition and diversification of metastatic abilities.

Original languageEnglish (US)
Pages (from-to)8536-8539
Number of pages4
JournalCancer Research
Issue number22
StatePublished - Nov 15 2009

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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