Cell depletion in synthetic micro-thrombosis: On the enhanced FåHraeus effect

Magalie Faivre; Manouk Abkarian; Kimberly Bikraj; Howard A. Stone

Cell depletion in synthetic micro-thrombosis: On the enhanced FåHraeus effect

Magalie Faivre, Manouk Abkarian, Kimberly Bikraj, Howard A. Stone

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

It is well known that when a suspension of cells flows in a small capillary there exists a cell-free layer adjacent to the walls. We show experimentally that a constriction in the flow can dramatically enhance the cell-free layer downstream. The effects of the constriction geometry, flow rate, suspending fluid viscosity, cell concentration, and cell deformability are studied and the results are interpreted in terms of a model of the hydrodynamic drift of a cell in a quadratic flow. As our observations indicate that the constriction causes dramatic modifications of the cell distribution, the results may have major implications for shear stress-triggered mechanotransduction, oxygen transport, and wound healing downstream of remodeled arteries.

Original language	English (US)
Title of host publication	05AIChE
Subtitle of host publication	2005 AIChE Annual Meeting and Fall Showcase, Conference Proceedings
Number of pages	1
State	Published - Dec 1 2005
Event	05AIChE: 2005 AIChE Annual Meeting and Fall Showcase - Cincinnati, OH, United States Duration: Oct 30 2005 → Nov 4 2005

Other

Other	05AIChE: 2005 AIChE Annual Meeting and Fall Showcase
Country/Territory	United States
City	Cincinnati, OH
Period	10/30/05 → 11/4/05

All Science Journal Classification (ASJC) codes

General Engineering

Cite this

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title = "Cell depletion in synthetic micro-thrombosis: On the enhanced F{\aa}Hraeus effect",

abstract = "It is well known that when a suspension of cells flows in a small capillary there exists a cell-free layer adjacent to the walls. We show experimentally that a constriction in the flow can dramatically enhance the cell-free layer downstream. The effects of the constriction geometry, flow rate, suspending fluid viscosity, cell concentration, and cell deformability are studied and the results are interpreted in terms of a model of the hydrodynamic drift of a cell in a quadratic flow. As our observations indicate that the constriction causes dramatic modifications of the cell distribution, the results may have major implications for shear stress-triggered mechanotransduction, oxygen transport, and wound healing downstream of remodeled arteries.",

author = "Magalie Faivre and Manouk Abkarian and Kimberly Bikraj and Stone, \{Howard A.\}",

year = "2005",

month = dec,

day = "1",

language = "English (US)",

booktitle = "05AIChE",

note = "05AIChE: 2005 AIChE Annual Meeting and Fall Showcase ; Conference date: 30-10-2005 Through 04-11-2005",

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T1 - Cell depletion in synthetic micro-thrombosis

T2 - 05AIChE: 2005 AIChE Annual Meeting and Fall Showcase

AU - Faivre, Magalie

AU - Abkarian, Manouk

AU - Bikraj, Kimberly

AU - Stone, Howard A.

PY - 2005/12/1

Y1 - 2005/12/1

N2 - It is well known that when a suspension of cells flows in a small capillary there exists a cell-free layer adjacent to the walls. We show experimentally that a constriction in the flow can dramatically enhance the cell-free layer downstream. The effects of the constriction geometry, flow rate, suspending fluid viscosity, cell concentration, and cell deformability are studied and the results are interpreted in terms of a model of the hydrodynamic drift of a cell in a quadratic flow. As our observations indicate that the constriction causes dramatic modifications of the cell distribution, the results may have major implications for shear stress-triggered mechanotransduction, oxygen transport, and wound healing downstream of remodeled arteries.

AB - It is well known that when a suspension of cells flows in a small capillary there exists a cell-free layer adjacent to the walls. We show experimentally that a constriction in the flow can dramatically enhance the cell-free layer downstream. The effects of the constriction geometry, flow rate, suspending fluid viscosity, cell concentration, and cell deformability are studied and the results are interpreted in terms of a model of the hydrodynamic drift of a cell in a quadratic flow. As our observations indicate that the constriction causes dramatic modifications of the cell distribution, the results may have major implications for shear stress-triggered mechanotransduction, oxygen transport, and wound healing downstream of remodeled arteries.

UR - https://www.scopus.com/pages/publications/33645560931

UR - https://www.scopus.com/inward/citedby.url?scp=33645560931&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:33645560931

BT - 05AIChE

Y2 - 30 October 2005 through 4 November 2005

ER -

Cell depletion in synthetic micro-thrombosis: On the enhanced FåHraeus effect

Abstract

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All Science Journal Classification (ASJC) codes

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