Cell attachment and spreading on metal implant materials

Jeffrey Schwartz, Michael J. Avaltroni, Michael P. Danahy, Brett M. Silverman, Eric L. Hanson, Jean E. Schwarzbauer, Kim S. Midwood, Ellen S. Gawalt

Research output: Contribution to journalArticlepeer-review

106 Scopus citations


Strong bonding and coverage of organic siloxanes or phosphonates on both Ti and Ti-Al-4V can be obtained using either of two novel metal-organic interfaces. Surface coverages are considerably higher than can be effected by direct silanization of the native oxide surfaces. Furthermore, these interfaces can be used to attach the fibronectin attachment peptide arginine-glycine-aspartic acid (RGD) to Ti-6Al-4V. Essentially, no osteoblast adhesion occurred on unmodified Ti-6Al-4V or on alkyl, ω-hydroxy, ω-carboxylic acid, or ω-carboxylateterminated alkylphosphonate-modified surfaces. Adhesion and spreading of osteoblasts on RGD-modified surfaces was quite substantial.

Original languageEnglish (US)
Pages (from-to)395-400
Number of pages6
JournalMaterials Science and Engineering C
Issue number3
StatePublished - Mar 3 2003

All Science Journal Classification (ASJC) codes

  • General Materials Science
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering


  • Osteoblast
  • RGD
  • Titanium


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