cats develop tolerance to d-amphetamine's effects upon locomotion and stereotyped behaviors

Barry L. Jacobs, James Heym, Michael E. Trulson

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Administration of d-amphetamine sulfate (7.5 mg/kg i.p.) twice daily to cats produces an initial large increase in both locomotion and behavioral stereotypy. As this regimen continues beyond three days, however, both measures show large significant decreases. We hypothesize that this tolerance to the behavioral effects of amphetamine is attributable to the concomitant decrease (approx. 70%) in presynaptic stores of dopamine and norepinephrine.

Original languageEnglish (US)
Pages (from-to)353-356
Number of pages4
JournalEuropean Journal of Pharmacology
Volume69
Issue number3
DOIs
StatePublished - Jan 29 1981

All Science Journal Classification (ASJC) codes

  • Pharmacology

Keywords

  • Cats
  • Dopamine
  • Locomotion
  • Norepinephrine
  • Stereotypy
  • Tolerance
  • d-Amphetamine

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