cats develop tolerance to d-amphetamine's effects upon locomotion and stereotyped behaviors

Barry L. Jacobs; James Heym; Michael E. Trulson

doi:10.1016/0014-2999(81)90482-9

cats develop tolerance to d-amphetamine's effects upon locomotion and stereotyped behaviors

Barry L. Jacobs, James Heym, Michael E. Trulson

Psychology

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Administration of d-amphetamine sulfate (7.5 mg/kg i.p.) twice daily to cats produces an initial large increase in both locomotion and behavioral stereotypy. As this regimen continues beyond three days, however, both measures show large significant decreases. We hypothesize that this tolerance to the behavioral effects of amphetamine is attributable to the concomitant decrease (approx. 70%) in presynaptic stores of dopamine and norepinephrine.

Original language	English (US)
Pages (from-to)	353-356
Number of pages	4
Journal	European Journal of Pharmacology
Volume	69
Issue number	3
DOIs	https://doi.org/10.1016/0014-2999(81)90482-9
State	Published - Jan 29 1981

All Science Journal Classification (ASJC) codes

Pharmacology

Keywords

Cats
Dopamine
Locomotion
Norepinephrine
Stereotypy
Tolerance
d-Amphetamine

Access to Document

10.1016/0014-2999(81)90482-9

Cite this

@article{6494395e9a8b4954806aa81428e43436,

title = "cats develop tolerance to d-amphetamine's effects upon locomotion and stereotyped behaviors",

abstract = "Administration of d-amphetamine sulfate (7.5 mg/kg i.p.) twice daily to cats produces an initial large increase in both locomotion and behavioral stereotypy. As this regimen continues beyond three days, however, both measures show large significant decreases. We hypothesize that this tolerance to the behavioral effects of amphetamine is attributable to the concomitant decrease (approx. 70%) in presynaptic stores of dopamine and norepinephrine.",

keywords = "Cats, Dopamine, Locomotion, Norepinephrine, Stereotypy, Tolerance, d-Amphetamine",

author = "Jacobs, {Barry L.} and James Heym and Trulson, {Michael E.}",

note = "Funding Information: This work was supported by National Institute of Mental Health grant MH 23433 and the Scottish Rite Schizophrenia Research Program, N.M.J., U.S.A.",

year = "1981",

month = jan,

day = "29",

doi = "10.1016/0014-2999(81)90482-9",

language = "English (US)",

volume = "69",

pages = "353--356",

journal = "European Journal of Pharmacology",

issn = "0014-2999",

publisher = "Elsevier B.V.",

number = "3",

}

TY - JOUR

T1 - cats develop tolerance to d-amphetamine's effects upon locomotion and stereotyped behaviors

AU - Jacobs, Barry L.

AU - Heym, James

AU - Trulson, Michael E.

N1 - Funding Information: This work was supported by National Institute of Mental Health grant MH 23433 and the Scottish Rite Schizophrenia Research Program, N.M.J., U.S.A.

PY - 1981/1/29

Y1 - 1981/1/29

N2 - Administration of d-amphetamine sulfate (7.5 mg/kg i.p.) twice daily to cats produces an initial large increase in both locomotion and behavioral stereotypy. As this regimen continues beyond three days, however, both measures show large significant decreases. We hypothesize that this tolerance to the behavioral effects of amphetamine is attributable to the concomitant decrease (approx. 70%) in presynaptic stores of dopamine and norepinephrine.

AB - Administration of d-amphetamine sulfate (7.5 mg/kg i.p.) twice daily to cats produces an initial large increase in both locomotion and behavioral stereotypy. As this regimen continues beyond three days, however, both measures show large significant decreases. We hypothesize that this tolerance to the behavioral effects of amphetamine is attributable to the concomitant decrease (approx. 70%) in presynaptic stores of dopamine and norepinephrine.

KW - Cats

KW - Dopamine

KW - Locomotion

KW - Norepinephrine

KW - Stereotypy

KW - Tolerance

KW - d-Amphetamine

UR - http://www.scopus.com/inward/record.url?scp=0019353180&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019353180&partnerID=8YFLogxK

U2 - 10.1016/0014-2999(81)90482-9

DO - 10.1016/0014-2999(81)90482-9

M3 - Article

C2 - 7194184

AN - SCOPUS:0019353180

SN - 0014-2999

VL - 69

SP - 353

EP - 356

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

IS - 3

ER -

cats develop tolerance to d-amphetamine's effects upon locomotion and stereotyped behaviors

Abstract

All Science Journal Classification (ASJC) codes

Keywords

Access to Document

Other files and links

Fingerprint

Cite this