Carboxyl methylation of protein phosphatase 2A from Xenopus eggs is stimulated by cAMP and inhibited by okadaic acid

Monique Floer, Jeffry Benton Stock

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

Protein phosphatase 2A is the principal carboxyl methylated protein in cytoplasmic extracts derived from Xenopus eggs arrested in interphase. Levels of methylation approach stoichiometric values after 2 hr of incubation at 22°C. Rates of PP2A methylation increase by over 50% upon addition of cAMP. Methylation is inhibited by okadaic acid at concentrations that inhibit PP2A phosphatase activity.

Original languageEnglish (US)
Pages (from-to)372-379
Number of pages8
JournalBiochemical and Biophysical Research Communications
Volume198
Issue number1
DOIs
StatePublished - Jan 15 1994

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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