Cancer stem cells and metastasis

Benjamin Tiede, Yibin Kang

Research output: Chapter in Book/Report/Conference proceedingChapter


Recent insights regarding the function of cancer stem cells are particularly intriguing when considered in the context of the metastatic cascade. As evidence for the direct involvement of cancer stem cells in initiating the growth of metastatic lesions is scant, this chapter will focus on known events in Malignant transformation that are likely to involve or affect cancer stem cells, which may give rise to primary tumors of varying degrees of Malignancy and metastatic potentials. The role of cancer stem cells in the later steps of the metastasis cascade will also be discussed. Finally, this chapter will explore potential characteristics vulnerabilities of cancer stem cells involved in metastasis, and speculate on how these weaknesses may be exploited to generate novel therapeutic and diagnostic approaches.

Original languageEnglish (US)
Title of host publicationCancer and Stem Cells
PublisherNova Science Publishers, Inc.
Number of pages16
ISBN (Electronic)9781616680442
ISBN (Print)9781604564785
StatePublished - Jan 1 2008

All Science Journal Classification (ASJC) codes

  • General Medicine
  • General Biochemistry, Genetics and Molecular Biology


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