Cancer stem cells and metastasis

Benjamin Tiede, Yibin Kang

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Recent insights regarding the function of cancer stem cells are particularly intriguing when considered in the context of the metastatic cascade. As evidence for the direct involvement of cancer stem cells in initiating the growth of metastatic lesions is scant, this chapter will focus on known events in malignant transformation that are likely to involve or affect cancer stem cells, which may give rise to primary tumors of varying degrees of malignancy and metastatic potentials. The role of cancer stem cells in the later steps of the metastasis cascade will also be discussed. Finally, this chapter will explore potential characteristics vulnerabilities of cancer stem cells involved in metastasis, and speculate on how these weaknesses may be exploited to generate novel therapeutic and diagnostic approaches.

Original languageEnglish (US)
Title of host publicationStem Cell Research
Subtitle of host publicationNew Developments
PublisherNova Science Publishers, Inc.
Pages235-250
Number of pages16
ISBN (Print)9781619420816
StatePublished - Dec 1 2012

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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  • Cite this

    Tiede, B., & Kang, Y. (2012). Cancer stem cells and metastasis. In Stem Cell Research: New Developments (pp. 235-250). Nova Science Publishers, Inc..