Caenorhabditis elegans recognizes a bacterial quorum-sensing signal molecule through theawcon neuron

Kristen M. Werner; Lark J. Perez; Rajarshi Ghosh; Martin F. Semmelhack; Bonnie Lynn Bassler

doi:10.1074/jbc.M114.573832

Caenorhabditis elegans recognizes a bacterial quorum-sensing signal molecule through theawcon neuron

Kristen M. Werner, Lark J. Perez, Rajarshi Ghosh, Martin F. Semmelhack, Bonnie Lynn Bassler

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Background: The nematode Caenorhabditis elegans consumes bacteria as its sole food source.

Results: The bacterium Vibrio cholerae produces a quorum-sensing signal molecule called CAI-1, which C. elegans detects through the AWCON chemosensory neuron.

Conclusion: C. elegans uses bacterial-produced molecules as cues, and these molecules are also physiologically significant to bacteria.

Significance: The V. cholerae molecule CAI-1 enables cross-kingdom chemical interaction.

Original language	English (US)
Pages (from-to)	26566-26573
Number of pages	8
Journal	Journal of Biological Chemistry
Volume	289
Issue number	38
DOIs	https://doi.org/10.1074/jbc.M114.573832
State	Published - Sep 19 2014

All Science Journal Classification (ASJC) codes

Molecular Biology
Biochemistry
Cell Biology

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title = "Caenorhabditis elegans recognizes a bacterial quorum-sensing signal molecule through theawcon neuron",

abstract = "Background: The nematode Caenorhabditis elegans consumes bacteria as its sole food source.Results: The bacterium Vibrio cholerae produces a quorum-sensing signal molecule called CAI-1, which C. elegans detects through the AWCON chemosensory neuron.Conclusion: C. elegans uses bacterial-produced molecules as cues, and these molecules are also physiologically significant to bacteria.Significance: The V. cholerae molecule CAI-1 enables cross-kingdom chemical interaction.",

author = "Werner, {Kristen M.} and Perez, {Lark J.} and Rajarshi Ghosh and Semmelhack, {Martin F.} and Bassler, {Bonnie Lynn}",

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AU - Werner, Kristen M.

AU - Perez, Lark J.

AU - Ghosh, Rajarshi

AU - Semmelhack, Martin F.

AU - Bassler, Bonnie Lynn

PY - 2014/9/19

Y1 - 2014/9/19

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AB - Background: The nematode Caenorhabditis elegans consumes bacteria as its sole food source.Results: The bacterium Vibrio cholerae produces a quorum-sensing signal molecule called CAI-1, which C. elegans detects through the AWCON chemosensory neuron.Conclusion: C. elegans uses bacterial-produced molecules as cues, and these molecules are also physiologically significant to bacteria.Significance: The V. cholerae molecule CAI-1 enables cross-kingdom chemical interaction.

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Caenorhabditis elegans recognizes a bacterial quorum-sensing signal molecule through theawcon neuron

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