Caenorhabditis elegans recognizes a bacterial quorum-sensing signal molecule through theawcon neuron

Kristen M. Werner, Lark J. Perez, Rajarshi Ghosh, Martin F. Semmelhack, Bonnie Lynn Bassler

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Background: The nematode Caenorhabditis elegans consumes bacteria as its sole food source.

Results: The bacterium Vibrio cholerae produces a quorum-sensing signal molecule called CAI-1, which C. elegans detects through the AWCON chemosensory neuron.

Conclusion: C. elegans uses bacterial-produced molecules as cues, and these molecules are also physiologically significant to bacteria.

Significance: The V. cholerae molecule CAI-1 enables cross-kingdom chemical interaction.

Original languageEnglish (US)
Pages (from-to)26566-26573
Number of pages8
JournalJournal of Biological Chemistry
Volume289
Issue number38
DOIs
StatePublished - Sep 19 2014

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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