Abstract
We describe the functionalization of α-amino C-H bonds with aryl halides using a combination of nickel and photoredox catalysis. This direct C-H, C-X coupling uses inexpensive and readily available starting materials to generate benzylic amines, an important class of bioactive molecules. Mechanistically, this method features the direct arylation of α-amino radicals mediated by a nickel catalyst. This reactivity is demonstrated for a range of aryl halides and N-aryl amines, with orthogonal scope to existing C-H activation and photoredox methodologies. We also report reactions with several complex aryl halides, demonstrating the potential utility of this approach in late-stage functionalization.
Original language | English (US) |
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Pages (from-to) | 7002-7006 |
Number of pages | 5 |
Journal | Chemical Science |
Volume | 7 |
Issue number | 12 |
DOIs | |
State | Published - 2016 |
All Science Journal Classification (ASJC) codes
- General Chemistry