TY - JOUR
T1 - Building branched tissue structures
T2 - From single cell guidance to coordinated construction
AU - Spurlin, James W.
AU - Nelson, Celeste M.
N1 - Funding Information:
Work from the authors’ lab was funded by the NIH, the NSF, the Burroughs Wellcome Fund, and a Faculty Scholars Award from the Howard Hughes Medical Institute.
Publisher Copyright:
© 2017 The Author(s) Published by the Royal Society. All rights reserved.
PY - 2017/5/19
Y1 - 2017/5/19
N2 - Branched networks are ubiquitous throughout nature, particularly found in tissues that require large surface area within a restricted volume. Many tissues with a branched architecture, such as the vasculature, kidney, mammary gland, lung and nervous system, function to exchange fluids, gases and information throughout the body of an organism. The generation of branched tissues requires regulation of branch site specification, initiation and elongation. Branching events often require the coordination of many cells to build a tissue network for material exchange. Recent evidence has emerged suggesting that cell cooperativity scales with the number of cells actively contributing to branching events. Here, we compare mechanisms that regulate branching, focusing on how cell cohorts behave in a coordinated manner to build branched tissues.
AB - Branched networks are ubiquitous throughout nature, particularly found in tissues that require large surface area within a restricted volume. Many tissues with a branched architecture, such as the vasculature, kidney, mammary gland, lung and nervous system, function to exchange fluids, gases and information throughout the body of an organism. The generation of branched tissues requires regulation of branch site specification, initiation and elongation. Branching events often require the coordination of many cells to build a tissue network for material exchange. Recent evidence has emerged suggesting that cell cooperativity scales with the number of cells actively contributing to branching events. Here, we compare mechanisms that regulate branching, focusing on how cell cohorts behave in a coordinated manner to build branched tissues.
KW - Actomyosin
KW - Branching motifs
KW - Collective migration
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U2 - 10.1098/rstb.2015.0527
DO - 10.1098/rstb.2015.0527
M3 - Review article
C2 - 28348257
AN - SCOPUS:85016329339
SN - 0962-8436
VL - 372
JO - Philosophical Transactions of the Royal Society B: Biological Sciences
JF - Philosophical Transactions of the Royal Society B: Biological Sciences
IS - 1720
M1 - 20150527
ER -